| Literature DB >> 5136461 |
G R Breese, J L Howard, J P Leahy.
Abstract
In rats, after a single intracisternal injection of 6-hydroxydopamine (6-OHDA) electrical self stimulation was reduced by approximately 50%. The concentrations of noradrenaline and dopamine in the brain were reduced by 83%. A second injection of 6-OHDA reduced the concentration of these amines to 7% of control values and virtually eliminated self stimulation.Entities:
Mesh：
Substances：
Year: 1971 PMID： 5136461 PMCID： PMC1665933 DOI： 10.1111/j.1476-5381.1971.tb07177.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739