| Literature DB >> 4315436 |
Abstract
Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.Entities:
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Year: 1970 PMID: 4315436 DOI: 10.1126/science.168.3937.1370
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728