Literature DB >> 5350323

Lesions of central norepinephrine terminals with 6-OH-dopamine: biochemistry and fine structure.

F E Bloom, S Algeri, A Groppetti, A Revuelta, E Costa.   

Abstract

Intracisternal injections of 6-hydroxydopamine produce rapid and long-lasting depletion of brain catecholamines without effects on serotonin concentrations. Depletion of norepinephrine is greatest in areas containing only nerve terminals and axons and least in areas containing monoamine cell bodies. The norepinephrine loss is accompanied by electron microscopic evidence of nerve terminal degeneration and decreased turnover. Dopamine loss is less marked and is not accompanied by degeneration or alteration of turnover rate.

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Year:  1969        PMID： 5350323     DOI： 10.1126/science.166.3910.1284

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  53 in total

1.  Effects of 6-hydroxydopamine and reserpine on aggressive behavior induced by cholinomimetic and anticholinesterase injections into cerebral ventricles of conscious cats: dissociation of biting attack from snarling and hissing.

Authors:  D B Beleslin; R Samardzić
Journal:  Psychopharmacology (Berl)       Date:  1979-03-22       Impact factor: 4.530

2.  Partial selectivity of 6-OHDA induced neuronal degeneration after intraissular injection in the brain with special reference to the nigro-striatal dopamine system.

Authors:  F Javoy
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

3.  Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei.

Authors:  G A Ordway; C A Stockmeier; G W Cason; V Klimek
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

4.  BIOCHEMICAL AND BEHAVIOURAL ALTERATIONS FOLLOWING 6-HYDROXYDOPAMINE ADMINISTRATION INTO BRAIN.

Authors:  George R Breese; Barrett R Cooper; Ronald D Smith
Journal:  Biochem Pharmacol       Date:  1974-04       Impact factor: 5.858

5.  Effects of hypothalamic noradrenaline depletion with 6-hydroxydopamine on the body temperature regulation of the rat.

Authors:  M T Lin; L R Shian; S Y Leu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-02       Impact factor: 3.000

6.  Effects of imipramine and desipramine on responses of single cortical neurones to noradrenaline and 5-hydroxytryptamine.

Authors:  C M Bradshaw; M H Roberts; E Szabadi
Journal:  Br J Pharmacol       Date:  1974-11       Impact factor: 8.739

7.  Effect of 6-hydroxydopamine on electrical self stimulation of the brain.

Authors:  G R Breese; J L Howard; J P Leahy
Journal:  Br J Pharmacol       Date:  1971-09       Impact factor: 8.739

8.  Role of catecholamines in the hypothermic activity of cannabis in albino rats.

Authors:  P P Singh; P K Das
Journal:  Psychopharmacology (Berl)       Date:  1976-11-10       Impact factor: 4.530

9.  Influence of 6-hydroxydopamine on the behavioral effects induced by apomorphine or clonidine in rats.

Authors:  Z S Herman; R Brus; A Drybański; R Szkilnik; J Slomińska-Zurek
Journal:  Psychopharmacology (Berl)       Date:  1976-10-20       Impact factor: 4.530

10.  The effects of a permanent and selective depletion of brain catecholamines on the antinociceptive action of morphine.

Authors:  P Slater; C Blundell
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-12       Impact factor: 3.000
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