Literature DB >> 5131737

Tentative identification of a vasopressin-neurophysin and an oxytocin-neurophysin in the rat.

G D Burford, C W Jones, B T Pickering.   

Abstract

1. Rat neurohypophysial extracts have been examined by polyacrylamide-gel electrophoresis. 2. Three of the proteins were tentatively identified as neurophysins by their acidic nature and their disappearance after dehydration of the animals. 3. These proteins were radioactive 24h after intracisternal injection of [(35)S]cysteine. 4. Two of the proteins were present in much greater quantities than the third, and these two were present in the gland in the same ratio as the hormones vasopressin and oxytocin. 5. One of these proteins was absent from glands of rats homozygous for diabetes insipidus but present in heterozygous animals. 6. It is suggested that these two proteins are the vasopressin-neurophysin and oxytocin-neurophysin of the rat.

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Year:  1971        PMID： 5131737      PMCID： PMC1177259          DOI： 10.1042/bj1240809

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

1.  The isolation of purified neurosecretory granules from bovine pituitary posterior lobes. Comparison of granule protein constituents with those of neurophysin.

Authors:  C R Dean; D B Hope
Journal:  Biochem J       Date:  1967-09       Impact factor: 3.857

2.  Dissociation of oxytocin and vasopressin from their carrier protein by chromatography on sephadex G-25.

Authors:  B T Frankland; M D Hollenberg; D B Hope; B A Schacter
Journal:  Br J Pharmacol Chemother       Date:  1966-02

3.  A study of proteins of the posterior pituitary of normal and dehydrated rats using disc electrophoresis.

Authors:  M L Rennels
Journal:  Endocrinology       Date:  1966-03       Impact factor: 4.736

4.  Neurohypophysial principles in rats homozygous and heterozygous for hypothalamic diabetes insipidus (Brattleboro strain).

Authors:  H Valtin; W H Sawyer; H W Sokol
Journal:  Endocrinology       Date:  1965-10       Impact factor: 4.736

5.  An acrylamide gel soluble in scintillation fluids: its application to electrophoresis at neutral and low pH.

Authors:  G L Choules; B H Zimm
Journal:  Anal Biochem       Date:  1965-11       Impact factor: 3.365

6.  High-efficiency liquid-scintillation counting of 14C-labelled material in aqueous solution and determination of specific activity of labelled proteins.

Authors:  T C Hall; E C Cocking
Journal:  Biochem J       Date:  1965-09       Impact factor: 3.857

7.  A potential source of electrophoretic artifacts in polyacrylamide gels.

Authors:  W M Mitchell
Journal:  Biochim Biophys Acta       Date:  1967-09-19

8.  Changes in neurohypophysial proteins induced by dehydration and ingestion of saline.

Authors:  H G Friesen; E B Astwood
Journal:  Endocrinology       Date:  1967-02       Impact factor: 4.736

9.  The role of neurophysin in the transport and release of neurohypophysical hormones.

Authors:  M Ginsburg; M Ireland
Journal:  J Endocrinol       Date:  1966-07       Impact factor: 4.286

10.  Artifact produced in disc electrophoresis by ammonium persulfate.

Authors:  J M Brewer
Journal:  Science       Date:  1967-04-14       Impact factor: 47.728
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  20 in total

1.  Isolation, assay, and secretion of individual human neurophysins.

Authors:  A G Robinson
Journal:  J Clin Invest       Date:  1975-02       Impact factor: 14.808

2.  Influence of adrenalectomy on "Gomori-positive" substances in the hypothalamo-neurohypophysial system of rats heterozygous and homozygous for hypothalamic diabetes insipidus.

Authors:  P E Schwabedal; R Bock; W B Watkins; J Möhring
Journal:  Anat Embryol (Berl)       Date:  1977-08-09

3.  Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin.

Authors:  D W Lincoln; J B Wakerley
Journal:  J Physiol       Date:  1974-10       Impact factor: 5.182

4.  Synthesis of both neurohypophysial hormones in both the paraventricular and supraoptic nuclei of the rat.

Authors:  G D Burford; R E Dyball; R L Moss; B T Pickering
Journal:  J Anat       Date:  1974-04       Impact factor: 2.610

5.  The number of neurophysins in the rat. Influence of the concentration of Bromophenol Blue, used as a tracking dye, on the resolution of proteins by polyacrylamide-gel electrophoresis.

Authors:  G D Burford; B T Pickering
Journal:  Biochem J       Date:  1972-07       Impact factor: 3.857

6.  Intra-axonal transport and turnover of neurohypophysial hormones in the rat.

Authors:  C W Jones; B T Pickering
Journal:  J Physiol       Date:  1972-12       Impact factor: 5.182

7.  Intra-axonal transport and turnover of neurophysins in the rat. A proposal for a possible origin of the minor neurophysin component.

Authors:  G D Burford; B T Pickering
Journal:  Biochem J       Date:  1973-12       Impact factor: 3.857

8.  Immunocytochemical study of the hypothalamo-neurohypophysial system. II. Distribution of neurophysin, vasopressin and oxytocin in the normal and osmotically stimulated rat.

Authors:  V J Choy; W B Watkins
Journal:  Cell Tissue Res       Date:  1977-06-13       Impact factor: 5.249

9.  Immunocytochemical study of the hypothalamo-neurohypophysial system. III. Localization of oxytocin- and vasopressin-containing neurons in the pig hypothalamus.

Authors:  W B Watkins; V J Choy
Journal:  Cell Tissue Res       Date:  1977-06-13       Impact factor: 5.249

10.  Subcellular organization of neurophysins, oxytocin, (8-lysine)-vasopressin and adenosine triphosphatase in porcine posterior pituitary lobes.

Authors:  J C Pickup; C I Johnston; S Nakamura; L O Uttenthal; D B Hope
Journal:  Biochem J       Date:  1973-03       Impact factor: 3.857
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