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Literature DB >> 5032783

Immunological abnormalities and hydantoins.

Abstract

Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins. Immunoglobulin A (IgA) was shown to be absent or low in five patients, beta(1)C/A was low in 10 patients. Five patients showed negative reactions to skin tests, and two could not be sensitized to dinitrochlorobenzene. The corresponding features were normal in 14 control patients with epilepsy but without hydantoins. It is suggested that the hydantoins influence humoral immunity, whereas other immunosuppressant agents have been found to affect cellular immunity.

Entities: Chemical Disease Gene Species

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Year: 1972 PMID： 5032783 PMCID： PMC1788121 DOI： 10.1136/bmj.2.5813.561

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

22 in total

1. DIPHENYLHYDANOIN-INDUCED HYPERSENSITIVITY REACTION.

Authors: P HOLLAND; A M MAUER
Journal: J Pediatr Date: 1965-02 Impact factor: 4.406

2. Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states.

Authors: C D WEST; R HONG; N H HOLLAND
Journal: J Clin Invest Date: 1962-11 Impact factor: 14.808

3. Lupus erythematosus disseminatus after administration of mesantoin; report of two cases.

Authors: T LINDQVIST
Journal: Acta Med Scand Date: 1957-08-13

4. [Lymph node manifestations during methyl-phenyl-ethyl-hydantoin therapy].

Authors: J OLMER; J PAILLAS; J ROGER; R MURATORE; M BADIER
Journal: Presse Med Date: 1952-12-25 Impact factor: 1.228

5. [L.E. phenomenon in two cases of drug hypersensitivity].

Authors: P MIESCHER; J DELACRETAZ
Journal: Schweiz Med Wochenschr Date: 1953-06-06

6. Dilantin sensitivity; report of a case of hepatitis with jaundice, pyrexia and exfoliative dermatitis.

Authors: B H CHAIKEN; B I GOLDBERG; J P SEGAL
Journal: N Engl J Med Date: 1950-06-08 Impact factor: 91.245

7. Deficiency of immunoglobulin A in intestinal disease.

Authors: D M Bull; T B Tomasi
Journal: Gastroenterology Date: 1968-02 Impact factor: 22.682

8. Lymphocytic thyroiditis possibly induced by diphenylhydantoin.

Authors: J J Kuiper
Journal: JAMA Date: 1969-12-29 Impact factor: 56.272

9. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

10. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.

Authors: A H COONS; M H KAPLAN
Journal: J Exp Med Date: 1950-01-01 Impact factor: 14.307

20 in total

1. False positive infectious mononucleosis serology in epilepsy.

Authors: P J Hamilton; E Edmond; R J Davidson
Journal: J Clin Pathol Date: 1975-10 Impact factor: 3.411

Review 2. Immunoglobulins in epilepsy.

Authors: J A Aarli
Journal: Springer Semin Immunopathol Date: 1985

Immunological abnormalities and hydantoins.

1. DIPHENYLHYDANOIN-INDUCED HYPERSENSITIVITY REACTION.

2. Immunoglobulin levels from the newborn period to adulthood and in immunoglobulin deficiency states.

3. Lupus erythematosus disseminatus after administration of mesantoin; report of two cases.

4. [Lymph node manifestations during methyl-phenyl-ethyl-hydantoin therapy].

5. [L.E. phenomenon in two cases of drug hypersensitivity].

6. Dilantin sensitivity; report of a case of hepatitis with jaundice, pyrexia and exfoliative dermatitis.

7. Deficiency of immunoglobulin A in intestinal disease.

8. Lymphocytic thyroiditis possibly induced by diphenylhydantoin.

9. Immunochemical quantitation of antigens by single radial immunodiffusion.

10. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.

1. False positive infectious mononucleosis serology in epilepsy.

Review 2. Immunoglobulins in epilepsy.

3. Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.

4. Lymphocytotoxins in epileptic patients receiving phenytoin.

5. Phenytoin promotes Th2 type immune response in mice.

6. The protective effect of hydantoin treatment on carcinogenesis.

7. Serum immunoglobulins in epileptic patients on anticonvulsant monotherapy.

8. Immunological abnormalities and HLA antigen frequencies in IgA deficient patients with epilepsy.

9. Morphological changes in the lymphoid organs induced by diphenylhydantoin sodium (DPH).

Review 10. Immunological adverse effects of anticonvulsants. What is their clinical relevance?