Literature DB >> 827086

Morphological changes in the lymphoid organs induced by diphenylhydantoin sodium (DPH).

I G Lorand, W A Hadler, L S Prigenzi.   

Abstract

In rats injected with DPH the morphological changes induced in the thymus and lymph nodes were studied. In the thymus, features suggesting block of cellular differentiation were found, and in lymph nodes depletion of the paracortical zone and intense plasma cell hyperplasia could be observed. The correlation of these findings with the functional changes in the immunological response induced by the drug, and the possible implications of these changes in the induction of lymphoma are discussed.

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Year:  1976        PMID: 827086     DOI: 10.1007/BF00429719

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histol        ISSN: 0340-1227


  28 in total

1.  [Lymphadenopathy induced by anticonvulsant drugs. Experimental study].

Authors:  L K DE SRULIJES; A PAVLOVSKY; E A PEDACE
Journal:  Medicina (B Aires)       Date:  1963 Jan-Feb       Impact factor: 0.653

2.  Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas.

Authors:  S L SALTZSTEIN; L V ACKERMAN
Journal:  Cancer       Date:  1959 Jan-Feb       Impact factor: 6.860

3.  [Experimental production of lymph node swellings by feeding of mesantoin].

Authors:  E KASLARIS
Journal:  Wien Klin Wochenschr       Date:  1953-12-11       Impact factor: 1.704

4.  Ultrastructure of the rat thymus. A transmission, scanning electron microscope, and morphometric study.

Authors:  W S Hwang; T Y Ho; S C Luk; G T Simon
Journal:  Lab Invest       Date:  1974-11       Impact factor: 5.662

5.  Antinuclear antibodies in patients on anticonvulsant therapy.

Authors:  D Alarcón-Segovia; E Fishbein; P A Reyes; H Díes; S Shwadsky
Journal:  Clin Exp Immunol       Date:  1972-09       Impact factor: 4.330

6.  Hydantoin-induced pseudo-pseudolymphoma.

Authors:  R A Gams; J A Neal; F G Conrad
Journal:  Ann Intern Med       Date:  1968-09       Impact factor: 25.391

7.  Malignant lymphoma associated with hydantoin drugs.

Authors:  J J Anthony
Journal:  Arch Neurol       Date:  1970-05

8.  Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).

Authors:  T C Sorrell; I J Forbes; F R Burness; R H Rischbieth
Journal:  Lancet       Date:  1971-12-04       Impact factor: 79.321

9.  Immunological abnormalities and hydantoins.

Authors:  P J Grob; G E Herold
Journal:  Br Med J       Date:  1972-06-03

10.  Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.

Authors:  G F Mitchell; J F Miller
Journal:  J Exp Med       Date:  1968-10-01       Impact factor: 14.307

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