Literature DB >> 5014442

Acetylcholine receptors: number and distribution at neuromuscular junctions in rat diaphragm.

D M Fambrough, H C Hartzell.   

Abstract

The number of acetylcholine receptors per motor end plate in the rat diaphragm, measured by the binding of [(125)1]alpha-bungarotoxin, varies directly with rat size and is (4.0 +/- 0.2) x 10(7) for full-grown male rats. Autoradiographic analysis of single fibers labeled with this substance reveals that virtually all of these receptors are localized in the end plate.

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Year:  1972        PMID： 5014442     DOI： 10.1126/science.176.4031.189

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

1.  Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.

Authors:  S J Burden; H C Hartzell; D Yoshikami
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

2.  Activation of membrane Na+/K+-ATPase of mouse skeletal muscle by acetylcholine and its inhibition by alpha-bungarotoxin, curare and atropine.

Authors:  H Dlouhá; J Teisinger; F Vyskocil
Journal:  Pflugers Arch       Date:  1979-05-15       Impact factor: 3.657

3.  Effects of chronic treatment with various neuromuscular blocking agents on the number and distribution of acetylcholine receptors in the rat diaphragm.

Authors:  C C Chang; S T Chuang; M C Huang
Journal:  J Physiol       Date:  1975-08       Impact factor: 5.182

4.  Increased extrajunctional acetylcholine sensitivity produced by chronic acetylcholine sensitivity produced by chronic post-synaptic neuromuscular blockade.

Authors:  D K Berg; Z W Hall
Journal:  J Physiol       Date:  1975-01       Impact factor: 5.182

5.  The distribution of acetylcholine sensitivity at the post-synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range.

Authors:  S W Kuffler; D Yoshikami
Journal:  J Physiol       Date:  1975-01       Impact factor: 5.182

6.  Discrimination between nicotinic receptors in vertebrate ganglia and skeletal muscle by alpha-bungarotoxin and cobra venoms.

Authors:  S Bursztajn; M D Gershon
Journal:  J Physiol       Date:  1977-07       Impact factor: 5.182

7.  The distribution of alpha-bungarotoxin binding sites of mammalian skeletal muscle developing in vivo.

Authors:  S Bevan; J H Steinbach
Journal:  J Physiol       Date:  1977-05       Impact factor: 5.182

8.  Antigenic similarity between the protein neurotoxin alpha-bungarotoxin and neuromuscular blocking drugs.

Authors:  D G Harle; B A Baldo; M M Fisher
Journal:  Agents Actions       Date:  1986-08

9.  Appearance of acetylcholine receptors during differentiation of a myogenic cell line.

Authors:  J Patrick; S F Heinemann; J Lindstrom; D Schubert; J H Steinbach
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

10.  Acetylcholinesterase activity in intact and homogenized skeletal muscle of the frog.

Authors:  R Miledi; P C Molenaar; R L Polak
Journal:  J Physiol       Date:  1984-04       Impact factor: 5.182
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