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Literature DB >> 1081230

Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.

Abstract

Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, like those from all other vertebrates previously tested, are blocked by these alpha-neurotoxins. In contrast, receptors from snakes and advanced lizards are insensitive to one or both of the toxins. It is suggested that toxin-resistant acetylcholine receptors appeared early in the evolution of Squamata and preceded the appearance of alpha-neurotoxins.

Entities: Chemical

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Year: 1975 PMID： 1081230 PMCID： PMC432959 DOI： 10.1073/pnas.72.8.3245

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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Authors: Karen de Morais-Zani; Kathleen Fernandes Grego; Aparecida Sadae Tanaka; Anita Mitico Tanaka-Azevedo
Journal: Int J Proteomics Date: 2013-04-22