Literature DB >> 3766310

Antigenic similarity between the protein neurotoxin alpha-bungarotoxin and neuromuscular blocking drugs.

D G Harle, B A Baldo, M M Fisher.   

Abstract

The snake neurotoxins alpha-bungarotoxin (alpha-BGT) and beta-bungarotoxin (beta-BGT) which act at the neuromuscular junction, were found to bind to IgE antibodies directed against neuromuscular blocking (NMB) drugs in the sera of two patients who had experienced lifethreatening anaphylactic reactions to succinylcholine. alpha-BGT inhibited IgE-binding to a choline-Sepharose solid support in one patient better than the NMB drug alcuronium, choline, triethylcholine and beta-BGT. IC50s for alpha-BGT and succinylcholine were 16 and 10 nmol respectively for one patient and 34 and 6.0 nmol for the other. Recognition of the NMB drugs and alpha-BGT by the same antibody is the first demonstration of an antigenic similarity between these drugs and the protein toxin.

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Year:  1986        PMID： 3766310     DOI： 10.1007/bf01964956

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  29 in total

1.  The crystal structure of a post-synaptic neurotoxin from sea snake at A resolution.

Authors:  D Tsernoglou; G A Petsko
Journal:  FEBS Lett       Date:  1976-09-15       Impact factor: 4.124

2.  Three-dimensional structure of neurotoxin a from venom of the Philippines sea snake.

Authors:  D Tsernoglou; G A Petsko
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

3.  Development of acetylcholine receptor clusters on cultured muscle cells.

Authors:  A J Sytkowski; Z Vogel; M W Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

4.  A protein inhibitor of acid deoxyribonucleases.

Authors:  P Lesca; C Paoletti
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205

5.  kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe.

Authors:  G A Grant; V A Chiappinelli
Journal:  Biochemistry       Date:  1985-03-12       Impact factor: 3.162

6.  Cross-reactivity of metocurine, atracurium, vecuronium and fazadinium with IgE antibodies from patients unexposed to these drugs but allergic to other myoneural blocking drugs.

Authors:  D G Harle; B A Baldo; M M Fisher
Journal:  Br J Anaesth       Date:  1985-11       Impact factor: 9.166

7.  Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization.

Authors:  R R Neubig; N D Boyd; J B Cohen
Journal:  Biochemistry       Date:  1982-07-06       Impact factor: 3.162

8.  Appearance of acetylcholine receptors during differentiation of a myogenic cell line.

Authors:  J Patrick; S F Heinemann; J Lindstrom; D Schubert; J H Steinbach
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

9.  Anaphylaxis to muscle relaxant drugs: cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay.

Authors:  B A Baldo; M M Fisher
Journal:  Mol Immunol       Date:  1983-12       Impact factor: 4.407

10.  Functional stoichiometry at the nicotinic receptor. The photon cross section for phase 1 corresponds to two bis-Q molecules per channel.

Authors:  R E Sheridan; H A Lester
Journal:  J Gen Physiol       Date:  1982-10       Impact factor: 4.086
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