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Literature DB >> 500784

The time course of mandelic and phenylglyoxylic acid excretion in workers exposed to styrene under model conditions.

H K Wilson, J Cocker, C J Purnell, R H Brown, D Gompertz.

Abstract

Urinary excretion of mandelic and phenylglyoxylic acids by two technicians building glass-reinforced plastic boats has been measured over a 7-day period. Peak excretion of both metabolites occurred several hours after the end of exposure. There was little relationship between urinary mandelic acid concentrations measured at the end of shift and the maximum excretion observed in samples collected after this time. It is suggested that sampling strategies devised to monitor workers exposed to styrene should reflect maximum excretion rates of urinary mandelic acid.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 500784 PMCID： PMC1008571 DOI： 10.1136/oem.36.3.235

Source DB: PubMed Journal: Br J Ind Med ISSN： 0007-1072

12 in total

1. The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites.

Authors: A J Ryan; J R Bend
Journal: Drug Metab Dispos Date: 1977 Jul-Aug Impact factor: 3.922

2. Human exposure to styrene. II. Quantitative and specific gaschromatographic analysis of urinary mandelic and phenylglyoxylic acids as an index of styrene exposure.

Authors: M Guillemin; D Bauer
Journal: Int Arch Occup Environ Health Date: 1976-04-28 Impact factor: 3.015

3. Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test.

Authors: K Engström; H Härkönen; P Kalliokoski; J Rantanen
Journal: Scand J Work Environ Health Date: 1976-03 Impact factor: 5.024

4. Measurement of personal exposure to 1,1,1-trichloroethane and trichloroethylene using an inexpensive sampling device and battery-operated pump.

Authors: J H Simmons; I M Moss
Journal: Ann Occup Hyg Date: 1973-04

5. A new method for determination of mandelic acid excretion at low level styrene exposure.

Authors: A Slob
Journal: Br J Ind Med Date: 1973-10

6. Biotransformation of ethyl benzene, styrene, and alpha-methylstyrene in man.

Authors: Z Bardodej; E Bardodejova
Journal: Am Ind Hyg Assoc J Date: 1970 Mar-Apr

7. The practical application of the Portion Diffusion Sampler for the measurement of time weighted average exposure to volatile organic substances in air.

Authors: M Evans; M Molyneux; T Sharp; A Bailey; P Hollingdale-Smith
Journal: Ann Occup Hyg Date: 1977-12

The time course of mandelic and phenylglyoxylic acid excretion in workers exposed to styrene under model conditions.

1. The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites.

2. Human exposure to styrene. II. Quantitative and specific gaschromatographic analysis of urinary mandelic and phenylglyoxylic acids as an index of styrene exposure.

3. Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test.

4. Measurement of personal exposure to 1,1,1-trichloroethane and trichloroethylene using an inexpensive sampling device and battery-operated pump.

5. A new method for determination of mandelic acid excretion at low level styrene exposure.

6. Biotransformation of ethyl benzene, styrene, and alpha-methylstyrene in man.

7. The practical application of the Portion Diffusion Sampler for the measurement of time weighted average exposure to volatile organic substances in air.

8. Simultaneous determination by gas chromatography of the major metabolites in urine of toluene, xylenes and styrene.

9. Evaluation of hippuric, phenylglyoxylic and mandelic acids in urine as indices of styrene exposure.

10. Metabolism and toxicity of styrene.

1. Styrene exposure and biologic monitoring in FRP boat production plants.

2. Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour.

3. Analysis and stability of phenylglyoxylic and mandelic acids in the urine of styrene-exposed people.

4. Evaluation of low exposure to styrene. I. Absorption of styrene vapours by inhalation under experimental conditions.