Literature DB >> 5002282

Immunoglobulin G and free kapa-chain synthesis in different clones of a hybrid cell line.

B Mohit.   

Abstract

13 clonal cell lines were isolated from a hybrid cell population established by cell fusion between cloned BALB/c myeloma cells that were resistant to 8-azaguanine and produced immunoglobulin G and free kappa chain and C(67)BL/6n lymphoma cells that were resistant to bromodeoxyuridine and did not produce immunoglobulins. Some of the histocompatibility-2 antigens of both parental cell lines could be demonstrated on all of the hybrid clones. 11 clones synthesized only free kappa chain. Two clones synthesized IgG of BALB/c type, as well as free kappa chain. These clones had higher chromosome number than did the clones that synthesized only kappa chains.

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Year:  1971        PMID： 5002282      PMCID： PMC389587          DOI： 10.1073/pnas.68.12.3045

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Differential activity of allelic gamma-globulin genes in antibody-producing cells.

Authors:  E Weiler
Journal:  Proc Natl Acad Sci U S A       Date:  1965-12       Impact factor: 11.205

2.  The lac operator is DNA.

Authors:  W Gilbert; B Müller-Hill
Journal:  Proc Natl Acad Sci U S A       Date:  1967-12       Impact factor: 11.205

Review 3.  Growth patterns of antibody-forming cell populations.

Authors:  T Makinodan; T Sado; D L Groves; G Price
Journal:  Curr Top Microbiol Immunol       Date:  1969       Impact factor: 4.291

4.  Identification and genetic control of two rabbit immunoglobulin allotypes at a second light chain locus, the c locus.

Authors:  A Gilman-Sachs; R G Mage; G O Young; C Alexander; S Dray
Journal:  J Immunol       Date:  1969-12       Impact factor: 5.422

5.  IgG synthesis in hybrid cells from an antibody-producing mouse myeloma and an L cell substrain.

Authors:  P Periman
Journal:  Nature       Date:  1970-12-12       Impact factor: 49.962

6.  Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization.

Authors:  R L Davidson; B Ephrussi; K Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1966-11       Impact factor: 11.205

7.  Hybrid cell line from a cloned immunoglobulin-producing mouse myeloma and a nonproducing mouse lymphoma.

Authors:  B Mohit; K Fan
Journal:  Science       Date:  1971-01-08       Impact factor: 47.728

8.  Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.

Authors:  T T PUCK; P I MARCUS; S J CIECIURA
Journal:  J Exp Med       Date:  1956-02-01       Impact factor: 14.307

9.  Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues.

Authors:  B Pernis; G Chiappino; A S Kelus; P G Gell
Journal:  J Exp Med       Date:  1965-11-01       Impact factor: 14.307

10.  Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.

Authors:  R W Dutton; R I Mishell
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307
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  5 in total

1.  Glucocorticoid action on hybrid clones derived from cultured myeloma and lymphoma cell lines.

Authors:  U Gehring; B Mohit; G M Tomkins
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

2.  Pattern of immunoglobulin synthesis and assembly in a human-mouse somatic cell hybrid clone.

Authors:  J Schwaber; E P Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

3.  Lambda-chain production in human lymphoblast-mouse fibroblast hybrids.

Authors:  S H Orkin; P D Buchanan; W J Yount; H Reisner; J W Littlefield
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

4.  High serum-free light chain levels and their rapid reduction in response to therapy define an aggressive multiple myeloma subtype with poor prognosis.

Authors:  Frits van Rhee; Vanessa Bolejack; Klaus Hollmig; Mauricio Pineda-Roman; Elias Anaissie; Joshua Epstein; John D Shaughnessy; Maurizio Zangari; Guido Tricot; Abid Mohiuddin; Yazan Alsayed; Gail Woods; John Crowley; Bart Barlogie
Journal:  Blood       Date:  2007-04-06       Impact factor: 22.113

5.  Induction of human immunoglobulin synthesis and secretion in somatic cell hybrids of mouse myeloma and human B lymphocytes from patients with agammaglobulinemia.

Authors:  J F Schwaber; F S Rosen
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307
  5 in total

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