Literature DB >> 4343956

Glucocorticoid action on hybrid clones derived from cultured myeloma and lymphoma cell lines.

U Gehring, B Mohit, G M Tomkins.   

Abstract

Cells of a cloned myeloma line from a Balb/c mouse contain specific cytoplasmic glucocorticoid receptors and are killed by dexamethasone. Cells of a lymphoma line (from mouse strain C57BL) also contain specific glucocorticoid receptors but are resistant to the steroid. Cells of two hybrid clones with widely differing chromosome numbers, derived by fusion between the resistant lymphoma and the sensitive myeloma, contain specific glucocorticoid receptors with similar binding properties as the parental receptors and are killed by dexamethasone. Since the lethal effect of the steroid is expressed in the hybrid cells, failure of the parent lymphoma line to be affected by dexamethasone is probably not due to an inhibitor of the lethal reaction.

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Year:  1972        PMID： 4343956      PMCID： PMC389718          DOI： 10.1073/pnas.69.11.3124

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

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Authors:  A G RUHMANN; D L BERLINER
Journal:  Endocrinology       Date:  1965-05       Impact factor: 4.736

2.  Response to cortisone and development of cortisone resistance in a cortisone-sensitive lymphosarcoma of the mouse.

Authors:  J M LAMPKIN; M POTTER
Journal:  J Natl Cancer Inst       Date:  1958-06       Impact factor: 13.506

3.  Differentiated functions expressed by cultured mouse lymphoma cells. I. Specificity and kinetics of cell responses to corticosteroids.

Authors:  A W Harris
Journal:  Exp Cell Res       Date:  1970-06       Impact factor: 3.905

4.  Stereospecific glucocorticoid binding to subcellular fractions of the sensitive and resistant lymphosarcoma P1798.

Authors:  A F Kirkpatrick; R J Milholland; F Rosen
Journal:  Nat New Biol       Date:  1971-08

5.  Evidence for induction by cortisol in vitro of a protein inhibitor of transport and phosphorylation processes in rat thymocytes.

Authors:  M H Makman; B Dvorkin; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

6.  Specificity and thermodynamic properties of the corticosteroid binding to a receptor of rat thymocytes in vitro.

Authors:  B P Schaumburg; E Bojesen
Journal:  Biochim Biophys Acta       Date:  1968-11-12

7.  Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity.

Authors:  J D Baxter; A W Harris; G M Tomkins; M Cohn
Journal:  Science       Date:  1971-01-15       Impact factor: 47.728

8.  Role of DNA and specific cytoplasmic receptors in glucocorticoid action.

Authors:  J D Baxter; G G Rousseau; M C Benson; R L Garcea; J Ito; G M Tomkins
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

9.  Hybrid cell line from a cloned immunoglobulin-producing mouse myeloma and a nonproducing mouse lymphoma.

Authors:  B Mohit; K Fan
Journal:  Science       Date:  1971-01-08       Impact factor: 47.728

10.  Studies in antibody response of mice to tumour inoculation.

Authors:  P A GORER
Journal:  Br J Cancer       Date:  1950-12       Impact factor: 7.640
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  7 in total

1.  Selective activation of a discrete family of endogenous proviral elements in normal BALB/c lymphocytes.

Authors:  J A Mietz; J W Fewell; E L Kuff
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

2.  Effects of adrenal glucocorticoids on polyoma virus replication.

Authors:  V Morhenn; Z Rabinowitz; G M Tomkins
Journal:  Proc Natl Acad Sci U S A       Date:  1973-04       Impact factor: 11.205

3.  Effect of cortisol on the ultrastructure of normal, leukemic, and cultured human lymphocytes.

Authors:  S Werthamer; L Amaral
Journal:  In Vitro       Date:  1975 Jul-Aug

4.  Assignment of the human gene for the glucocorticoid receptor to chromosome 5.

Authors:  U Gehring; B Segnitz; B Foellmer; U Francke
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

5.  Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages.

Authors:  Elisabeth Müller; Panagiotis F Christopoulos; Sanjib Halder; Anna Lunde; Kahsai Beraki; Martin Speth; Inger Øynebråten; Alexandre Corthay
Journal:  Front Immunol       Date:  2017-10-26       Impact factor: 7.561

Review 6.  Perturbing Enhancer Activity in Cancer Therapy.

Authors:  Feda H Hamdan; Steven A Johnsen
Journal:  Cancers (Basel)       Date:  2019-05-07       Impact factor: 6.639

7.  tRNA Derivatives in Multiple Myeloma: Investigation of the Potential Value of a tRNA-Derived Molecular Signature.

Authors:  Paraskevi Karousi; Aristea-Maria Papanota; Pinelopi I Artemaki; Christine-Ivy Liacos; Dimitrios Patseas; Nefeli Mavrianou-Koutsoukou; Aikaterini-Anna Liosi; Maria-Anna Kalioraki; Ioannis Ntanasis-Stathopoulos; Maria Gavriatopoulou; Efstathios Kastritis; Meletios-Athanasios Dimopoulos; Andreas Scorilas; Evangelos Terpos; Christos K Kontos
Journal:  Biomedicines       Date:  2021-12-01
  7 in total

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