Literature DB >> 497538

The effects of ions on the binding of agonists and antagonists to muscarinic receptors.

N J Birdsall, A S Burgen, E C Hulme, J W Wells.   

Abstract

1 There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl- on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. 2 Larger effects were produced by T1+, La3+, and some transition metal ions.

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Year:  1979        PMID： 497538      PMCID： PMC2043948          DOI： 10.1111/j.1476-5381.1979.tb08690.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  23 in total

1.  EFFECTS OF INTRACELLULAR POTASSIUM AND SODIUM INJECTIONS ON THE INHIBITORY POSTSYNAPTIC POTENTIAL.

Authors:  J ECCLES; R M ECCLES; M ITO
Journal:  Proc R Soc Lond B Biol Sci       Date:  1964-05-19

2.  ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

Authors:  J MONOD; J WYMAN; J P CHANGEUX
Journal:  J Mol Biol       Date:  1965-05       Impact factor: 5.469

3.  Further study on anion permeability of inhibitory post-synaptic membrane of cat motoneurones.

Authors:  M ITO; P G KOSTYUK; T OSHIMA
Journal:  J Physiol       Date:  1962-10       Impact factor: 5.182

4.  Some properties of conductance changes at the end-plate membrane during the action of acetylcholine.

Authors:  N TAKEUCHI
Journal:  J Physiol       Date:  1963-06       Impact factor: 5.182

5.  On the permeability of end-plate membrane during the action of transmitter.

Authors:  A TAKEUCHI; N TAKEUCHI
Journal:  J Physiol       Date:  1960-11       Impact factor: 5.182

6.  Strychinine binding associated with synaptic glycine receptors in rat spinal cord membranes: ionic influences.

Authors:  W E Muller; S H Snyder
Journal:  Brain Res       Date:  1978-05-19       Impact factor: 3.252

Review 7.  Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors.

Authors:  R J Lefkowitz; L T Williams
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

8.  Functional acetylcholine receptor--electroplax membrane microsacs (vesicles): purification and characterization.

Authors:  G P Hess; J P Andrews
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

9.  Permeant cations alter endplate channel characteristics.

Authors:  D Van Helden; O P Hamill; P W Gage
Journal:  Nature       Date:  1977-10-20       Impact factor: 49.962

10.  Life time and elementary conductance of the channels mediating the excitatory effects of acetylcholine in Aplysia neurones.

Authors:  P Ascher; A Marty; T O Neild
Journal:  J Physiol       Date:  1978-05       Impact factor: 5.182
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  14 in total

1.  Modulation of the structure-binding relationships of antagonists for muscarinic acetylcholine receptor subtypes.

Authors:  E K Pedder; P Eveleigh; D Poyner; E C Hulme; N J Birdsall
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

Review 2.  Ligand binding assays at equilibrium: validation and interpretation.

Authors:  Edward C Hulme; Mike A Trevethick
Journal:  Br J Pharmacol       Date:  2010-11       Impact factor: 8.739

3.  Proceedings of the British Pharmacological Society. University of Manchester, 13-15 September 1989.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

4.  Affinity of muscarinic receptor antagonists for three putative muscarinic receptor binding sites.

Authors:  R E Delmendo; A D Michel; R L Whiting
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

5.  Inhibition by cations of antagonist binding to histamine H1-receptors: differential effect of sodium ions on the binding of two radioligands.

Authors:  J M Treherne; J S Stern; W J Flack; J M Young
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

Review 6.  Harnessing Ion-Binding Sites for GPCR Pharmacology.

Authors:  Barbara Zarzycka; Saheem A Zaidi; Bryan L Roth; Vsevolod Katritch
Journal:  Pharmacol Rev       Date:  2019-10       Impact factor: 25.468

7.  Muscarinic cholinergic receptor binding in rat mast cells.

Authors:  E Masini; R Fantozzi; P Blandina; S Brunelleschi; P F Mannaioni
Journal:  Agents Actions       Date:  1983-06

8.  Requirement for sulfhydryl groups in the differential effects of magnesium ion and GTP on agonist binding of muscarinic cholinergic receptor sites in rat atrial membrane fraction.

Authors:  J W Wei; P V Sulakhe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

9.  Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors.

Authors:  X Hou; J Wehrle; W Menge; E Ciccarelli; J Wess; E Mutschler; G Lambrecht; H Timmerman; M Waelbroeck
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

10.  The effect of ionic strength on cardiac muscarinic receptors.

Authors:  A S Burgen
Journal:  Br J Pharmacol       Date:  1986-06       Impact factor: 8.739
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