Literature DB >> 4960935

An immunologic precipitin system between soluble nucleoprotein and serum antibody in systemic lupus erythematosus.

E M Tan.   

Abstract

Double diffusion in agarose was employed for the characterization of a soluble nucleoprotein antigen that gave precipitin reactions with sera from patients with systemic lupus erythematosus. The soluble antigen that was isolated from calf thymus nuclei was demonstrated by enzyme degradation and ultracentrifugation studies, and by immunologic analysis, to be a complex of deoxyribonucleic acid and a moiety susceptible to proteolytic digestion. Antibody to soluble nucleoprotein did not react with the DNA portion of the complex released after proteolytic digestion or with purified calf thymus DNA. Immunologic reaction of identity was obtained between the soluble nucleoprotein antigen and synthesized DNA-histone complex, suggesting that the protein moiety of soluble nucleoprotein might in part be composed of histone. Antibody to soluble nucleoprotein was present in 51% of systemic lupus erythematosus sera examined and was more common than antibody to deoxyribonucleic acid.

Entities:  

Mesh：

Substances：

Year:  1967        PMID： 4960935      PMCID： PMC297076          DOI： 10.1172/JCI105574

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  24 in total

1.  Variations in the morphological patterns of "autoimmune" nuclear fluorescence.

Authors:  J S BECK
Journal:  Lancet       Date:  1961-06-03       Impact factor: 79.321

2.  [Immunological studies on disseminated lupus erythematosus].

Authors:  M SELIGMANN
Journal:  Rev Fr Etud Clin Biol       Date:  1958-06

3.  Antibodies against nuclear and cytoplasmic cell constituents in systemic lupus erythematosus and other diseases.

Authors:  G L ASHERSON
Journal:  Br J Exp Pathol       Date:  1959-06

4.  An attempt to characterize the lupus erythematosus cell antigen.

Authors:  P J LACHMANN
Journal:  Immunology       Date:  1961-04       Impact factor: 7.397

5.  A two-stage indirect L.E. cell test.

Authors:  P J LACHMANN
Journal:  Immunology       Date:  1961-04       Impact factor: 7.397

6.  Correlation of antinuclear antibodies and nuclear staining patterns.

Authors:  P J LACHMANN; H G KUNKEL
Journal:  Lancet       Date:  1961-08-19       Impact factor: 79.321

7.  Complement fixation reactions with DNA and leukocyte material in systemic lupus erythematosus: correlation with the L. E. cell phenomenon and the clinical status.

Authors:  C M PEARSON; C G CRADDOCK; N S SIMMONS
Journal:  J Lab Clin Med       Date:  1958-10

8.  The reaction of the lupus erythematosus (L.E.) cell factor with deoxyribonucleoprotein of the cell nucleus.

Authors:  H HOLMAN; H R DEICHER
Journal:  J Clin Invest       Date:  1959-11       Impact factor: 14.808

9.  Nuclear polyanions as de-repressors of synthesis of ribonucleic acid.

Authors:  J H Frenster
Journal:  Nature       Date:  1965-05-15       Impact factor: 49.962

10.  The precipitin reaction between DNA and a serum factor in systemic lupus erythematosus.

Authors:  H R DEICHER; H R HOLMAN; H G KUNKEL
Journal:  J Exp Med       Date:  1959-01-01       Impact factor: 14.307
View more
  31 in total

1.  Immunoelectron microscopic evidence of contractile proteins in the cellular and acellular components of mouse kidney glomeruli.

Authors:  L Accinni; P G Natali; L Vassallo; K S Hsu; C De Martino
Journal:  Cell Tissue Res       Date:  1975-10-13       Impact factor: 5.249

2.  Contractile filaments in cells of regenerating tendon.

Authors:  F Postacchini; P G Natali; L Accinni; E Ippolito; C de Martino
Journal:  Experientia       Date:  1977-07-15

Review 3.  Clinical relevance of autoantibodies in systemic rheumatic diseases.

Authors:  M J Fritzler
Journal:  Mol Biol Rep       Date:  1996       Impact factor: 2.316

4.  Postnatal development of epididymis and ductus deferens in the rat. A correlation between the ultrastructure of the epithelium and tubule wall, and the fluorescence-microscopic distribution of actin, myosin, fibronectin, and basement membrane.

Authors:  S Francavilla; S Moscardelli; G Properzi; M A De Matteis; P Scorza Barcellona; P G Natali; C De Martino
Journal:  Cell Tissue Res       Date:  1987-08       Impact factor: 5.249

5.  Immunological detection of nucleic acids and antibodies to nucleic acids and nuclear antigens by counterimmunoelectrophoresis.

Authors:  P H Schur; D DeAngelis; J M Jackson
Journal:  Clin Exp Immunol       Date:  1974-05       Impact factor: 4.330

6.  Antigenic specificity of chlorpromazine-induced antinuclear antibodies.

Authors:  D Alarcón-Segovia; E Fishbein; J A Cetina; R J Raya; E Barrera
Journal:  Clin Exp Immunol       Date:  1973-12       Impact factor: 4.330

7.  Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

Authors:  P L Meroni; G de Bartolo; W Barcellini; P S Riboldi; R Basile; C Betterle; C Zanussi
Journal:  J Clin Immunol       Date:  1984-01       Impact factor: 8.317

8.  Antibodies to histones in drug-induced and idiopathic lupus erythematosus.

Authors:  M J Fritzler; E M Tan
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

9.  In vitro effect of antibodies to DNA on the template activity of DNA.

Authors:  J N Whitaker; J L Starr
Journal:  J Clin Invest       Date:  1968-07       Impact factor: 14.808

10.  A simple, rapid ELISA method for the detection of DNA antibodies.

Authors:  R P Stokes; A Cordwell; R A Thompson
Journal:  J Clin Pathol       Date:  1982-05       Impact factor: 3.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.