Literature DB >> 6421870

Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

P L Meroni, G de Bartolo, W Barcellini, P S Riboldi, R Basile, C Betterle, C Zanussi.   

Abstract

Sera from systemic lupus erythematosus (SLE) patients giving a fluorescent ribosomal pattern on tissue and cell preparations also showed precipitating autoantibodies against purified rat liver ribosomes. Ribosomal antigen is also present in rabbit thymus cellular extract (RTE), since the same sera gave precipitin lines against RTE in identity with ribosomes. Immunofluorescent staining was completely inhibited by serum absorption with ribosomes or with RTE. However ribosomal RNA and RNase or trypsin-treated ribosomes failed to react with these autoantibodies as demonstrated in immunoabsorption and immunodiffusion studies. These data suggest that these sera contain autoantibodies directed against some antigenic site composed of a portion of both RNA and ribosomal protein. Ribosomal autoantibodies were detectable at a low frequency in SLE patients characterized by an active disease and renal involvement.

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Year:  1984        PMID： 6421870     DOI： 10.1007/bf00915287

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  17 in total

1.  Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis.

Authors:  N Kurata; E M Tan
Journal:  Arthritis Rheum       Date:  1976 May-Jun

2.  Precise standardization of reagents for complement fixation.

Authors:  J F KENT; E H FIFE
Journal:  Am J Trop Med Hyg       Date:  1963-01       Impact factor: 2.345

3.  Antinucleolar antibodies in human sera.

Authors:  J L Pinnas; J D Northway; E M Tan
Journal:  J Immunol       Date:  1973-10       Impact factor: 5.422

4.  Ribosomal antibodies detected by immunofluorescence in systemic lupus erythematosus and other collagenoses.

Authors:  J C Homberg; M Rizzetto; D Doniach
Journal:  Clin Exp Immunol       Date:  1974-08       Impact factor: 4.330

5.  Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications.

Authors:  D Doniach; I M Roitt; J G Walker; S Sherlock
Journal:  Clin Exp Immunol       Date:  1966-07       Impact factor: 4.330

6.  Qualitative characteristics of anti-DNA antibodies in lupus nephritis.

Authors:  M E Gershwin; A D Steinberg
Journal:  Arthritis Rheum       Date:  1974 Nov-Dec

7.  Studies on the specificity and clinical correlation of antiribosomal antibodies in systemic lupus erythematosus sera.

Authors:  D Koffler; T E Miller; R G Lahita
Journal:  Arthritis Rheum       Date:  1979-05

8.  Antibodies reacting with ribosomal ribonucleoprotein in connective tissue diseases.

Authors:  K Miyachi; E M Tan
Journal:  Arthritis Rheum       Date:  1979-01

9.  Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.

Authors:  J B Winfield; I Faiferman; D Koffler
Journal:  J Clin Invest       Date:  1977-01       Impact factor: 14.808

10.  Complement-fixing islet-cell antibodies in type-I diabetes: possible monitors of active beta-cell damage.

Authors:  G F Bottazzo; B M Dean; A N Gorsuch; A G Cudworth; D Doniach
Journal:  Lancet       Date:  1980-03-29       Impact factor: 79.321
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  3 in total

1.  Anti-mitochondrial type M5 and anti-cardiolipin antibodies in autoimmune disorders: studies on their association and cross-reactivity.

Authors:  P L Meroni; E N Harris; A Brucato; A Tincani; W Barcellini; A Vismara; G Balestrieri; G R Hughes; C Zanussi
Journal:  Clin Exp Immunol       Date:  1987-03       Impact factor: 4.330

2.  Anti-endothelial cell antibodies in patients with Wegener's granulomatosis and micropolyarteritis.

Authors:  G Ferraro; P L Meroni; A Tincani; A Sinico; W Barcellini; A Radice; G Gregorini; M Froldi; M O Borghi; G Balestrieri
Journal:  Clin Exp Immunol       Date:  1990-01       Impact factor: 4.330

3.  Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody.

Authors:  N Chiorazzi; W H Reeves
Journal:  J Exp Med       Date:  1987-04-01       Impact factor: 14.307
  3 in total

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