| Literature DB >> 4942762 |
B Low, F Gates, T Goldstein, D Söll.
Abstract
Two temperature-sensitive mutants of Escherichia coli have been found in which the conditional growth is a result of a thermosensitive leucyl-transfer ribonucleic acid (tRNA) synthetase and seryl-tRNA synthetase, respectively. The corresponding genetic loci, leuS and serS, cotransduce with lip and serC, respectively. As a result of the mutationally altered leucyl-tRNA synthetase, some leucine-, valine-, and isoleucine-forming enzymes were derepressed. Thus, leucyl-tRNA synthetase is involved in the repression of the enzymes needed for the synthesis of branched-chain amino acids.Entities:
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Year: 1971 PMID: 4942762 PMCID: PMC247134 DOI: 10.1128/jb.108.2.742-750.1971
Source DB: PubMed Journal: J Bacteriol ISSN: 0021-9193 Impact factor: 3.490