Literature DB >> 4917818

Peptide chain termination with mammalian release factor.

J L Goldstein, A L Beaudet, C T Caskey.   

Abstract

We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N-formylmethionine from mammalian [N-formylmethionyl-tRNA(f).ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.

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Year:  1970        PMID： 4917818      PMCID： PMC283173          DOI： 10.1073/pnas.67.1.99

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Synthesis of trinucleoside diphosphates with polynucleotide phosphorylase.

Authors:  P Leder; M F Singer; R L Brimacombe
Journal:  Biochemistry       Date:  1965-08       Impact factor: 3.162

2.  Release factors differing in specificity for terminator codons.

Authors:  E Scolnick; R Tompkins; T Caskey; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1968-10       Impact factor: 11.205

3.  Sense and nonsense in the genetic code. Three exceptional triplets can serve as both chain-terminating signals and amino acid codons.

Authors:  A Garen
Journal:  Science       Date:  1968-04-12       Impact factor: 47.728

4.  Formylation of guinea pig liver methionyl-sRNA.

Authors:  C T Caskey; B Redfield; H Weissbach
Journal:  Arch Biochem Biophys       Date:  1967-04       Impact factor: 4.013

Review 5.  Mechanism of protein biosynthesis.

Authors:  P Lengyel; D Söll
Journal:  Bacteriol Rev       Date:  1969-06

6.  Studies on polynucleotides. LXXXIX. A study of amino acid incorporation in a reticulocyte cell-free protein-synthesizing system with polyribonucleotides with repeating nucleotide sequences used as messengers.

Authors:  N K Gupta
Journal:  J Biol Chem       Date:  1968-10-10       Impact factor: 5.157

7.  Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin.

Authors:  P Leder; H Bursztyn
Journal:  Biochem Biophys Res Commun       Date:  1966-10-20       Impact factor: 3.575

8.  Codon--anticodon pairing: the wobble hypothesis.

Authors:  F H Crick
Journal:  J Mol Biol       Date:  1966-08       Impact factor: 5.469

9.  Sequential translation of trinucleotide codons for the initiation and termination of protein synthesis.

Authors:  C T Caskey; R Tompkins; E Scolnick; T Caryk; M Nirenberg
Journal:  Science       Date:  1968-10-04       Impact factor: 47.728

10.  Fine structure of RNA codewords recognized by bacterial, amphibian, and mammalian transfer RNA.

Authors:  R E Marshall; C T Caskey; M Nirenberg
Journal:  Science       Date:  1967-02-17       Impact factor: 47.728
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  23 in total

1.  Sequence analysis suggests that tetra-nucleotides signal the termination of protein synthesis in eukaryotes.

Authors:  C M Brown; P A Stockwell; C N Trotman; W P Tate
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

2.  Allan Award Introduction: Arthur L. Beaudet.

Authors:  James R Lupski
Journal:  Am J Hum Genet       Date:  2008-05       Impact factor: 11.025

3.  Release factor RF-3 GTPase activity acts in disassembly of the ribosome termination complex.

Authors:  G Grentzmann; P J Kelly; S Laalami; M Shuda; M A Firpo; Y Cenatiempo; A Kaji
Journal:  RNA       Date:  1998-08       Impact factor: 4.942

4.  Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.

Authors:  C C Lee; W J Craigen; D M Muzny; E Harlow; C T Caskey
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

5.  Eukaryotic release factor 1 (eRF1) abolishes readthrough and competes with suppressor tRNAs at all three termination codons in messenger RNA.

Authors:  G Drugeon; O Jean-Jean; L Frolova; X Le Goff; M Philippe; L Kisselev; A L Haenni
Journal:  Nucleic Acids Res       Date:  1997-06-15       Impact factor: 16.971

Review 6.  The mechanism of peptide chain termination.

Authors:  W P Tate; C T Caskey
Journal:  Mol Cell Biochem       Date:  1974-12-20       Impact factor: 3.396

Review 7.  Termination of protein synthesis.

Authors:  M F Tuite; I Stansfield
Journal:  Mol Biol Rep       Date:  1994-05       Impact factor: 2.316

8.  Hydrolysis of fMet-tRNA by peptidyl transferase.

Authors:  C T Caskey; A L Beaudet; E M Scolnick; M Rosman
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

9.  Influence of guanine nucleotides and elongation factors on interaction of release factors with the ribosome.

Authors:  W P Tate; A L Beaudet; C T Caskey
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

Review 10.  Polypeptide chain termination in Saccharomyces cerevisiae.

Authors:  I Stansfield; M F Tuite
Journal:  Curr Genet       Date:  1994-05       Impact factor: 3.886
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