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Literature DB >> 4916921

Properties of a temperature-sensitive, radiation-sensitive mutant of Escherichia coli. II. DNA replication.

Abstract

We have described a temperature-sensitive, radiation-sensitive mutant of Escherichia coli. In vitro assays have demonstrated that DNA ligase activity is markedly reduced in this strain relative to that of the parent strain. Okazaki fragments of newly replicated DNA accumulate in this mutant strain upon growth at the restrictive temperature. These results imply that the same enzyme, DNA ligase, functions both in normal semiconservative replication and in nonconservative repair replication of DNA.

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Year: 1969 PMID： 4916921 PMCID： PMC223268 DOI： 10.1073/pnas.64.4.1195

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

8 in total

1. EVIDENCE FOR REPAIR-REPLICATION OF ULTRAVIOLET DAMAGED DNA IN BACTERIA.

Authors: D PETTIJOHN; P HANAWALT
Journal: J Mol Biol Date: 1964-08 Impact factor: 5.469

2. ISOLATION OF THE GROWING POINT IN THE BACTERIAL CHROMOSOME.

Authors: P C HANAWALT; D S RAY
Journal: Proc Natl Acad Sci U S A Date: 1964-07 Impact factor: 11.205

3. Involvement of synthesis of RNA in thymineless death.

Authors: P C HANAWALT
Journal: Nature Date: 1963-04-20 Impact factor: 49.962

4. Properties of a temperature-sensitive radiation-sensitive mutant of Escherichia coli.

Authors: C Pauling; L Hamm
Journal: Proc Natl Acad Sci U S A Date: 1968-08 Impact factor: 11.205

5. Formation of covalent circles of lambda DNA by E. coli extracts.

Authors: M Gellert
Journal: Proc Natl Acad Sci U S A Date: 1967-01 Impact factor: 11.205

6. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

Authors: R Okazaki; T Okazaki; K Sakabe; K Sugimoto; A Sugino
Journal: Proc Natl Acad Sci U S A Date: 1968-02 Impact factor: 11.205

7. Intermediates in T4 DNA replication in a T4 ligase deficient strain.

Authors: J Newman; P Hanawalt
Journal: Cold Spring Harb Symp Quant Biol Date: 1968

8. Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.

Authors: B M Olivera; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

8 in total

32 in total

1. Enhancement by nalidixic acid of the thermal susceptibility of the Ts-7 mutant of Escherichia coli TAU-bar.

Authors: M Nishida; Y Mishima; J Kawada; K L Yielding
Journal: Antimicrob Agents Chemother Date: 1975-09 Impact factor: 5.191

2. Role for deoxyribonucleic acid ligase in deoxyribonucleic acid polymerase i-dependent repair synthesis in toluene-treated escherichia coli.

Authors: D Billen; G R Hellermann; D R Stallions
Journal: J Bacteriol Date: 1975-10 Impact factor: 3.490

Review 7. Saccharomyces cerevisiae cell cycle.

Authors: L H Hartwell
Journal: Bacteriol Rev Date: 1974-06

Properties of a temperature-sensitive, radiation-sensitive mutant of Escherichia coli. II. DNA replication.

1. EVIDENCE FOR REPAIR-REPLICATION OF ULTRAVIOLET DAMAGED DNA IN BACTERIA.

2. ISOLATION OF THE GROWING POINT IN THE BACTERIAL CHROMOSOME.

3. Involvement of synthesis of RNA in thymineless death.

4. Properties of a temperature-sensitive radiation-sensitive mutant of Escherichia coli.

5. Formation of covalent circles of lambda DNA by E. coli extracts.

6. Mechanism of DNA chain growth. I. Possible discontinuity and unusual secondary structure of newly synthesized chains.

7. Intermediates in T4 DNA replication in a T4 ligase deficient strain.

8. Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.

1. Enhancement by nalidixic acid of the thermal susceptibility of the Ts-7 mutant of Escherichia coli TAU-bar.

2. Role for deoxyribonucleic acid ligase in deoxyribonucleic acid polymerase i-dependent repair synthesis in toluene-treated escherichia coli.

3. Temperature-sensitive mutant of Schizosaccharomyces pombe exhibiting enhanced radiation sensitivity.

4. Evidence that a single DNA ligase is involved in replication and recombination in yeast.

5. Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli.

6. Method for the isolation of Escherichia coli mutants with enhanced recombination between chromosomal duplications.

Review 7. Saccharomyces cerevisiae cell cycle.

8. Mechanism of replication of single-stranded PhiX174 DNA. VII. Circularization of the progeny viral strand.

9. Plasmid containing a DNA ligase gene from Haemophilus influenzae.

10. The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.