Literature DB >> 4909169

N'-(substituted) pantothenamides, antimetabolites of pantothenic acid.

G Clifton, S R Bryant, C G Skinner.   

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Year:  1970        PMID： 4909169     DOI： 10.1016/0003-9861(70)90470-4

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


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  19 in total

1.  Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity.

Authors:  Annabelle Hoegl; Hamed Darabi; Elisa Tran; Emelia Awuah; Eleanor S C Kerdo; Eric Habib; Kevin J Saliba; Karine Auclair
Journal:  Bioorg Med Chem Lett       Date:  2014-06-18       Impact factor: 2.823

2.  Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.

Authors:  T Olukayode Akinnusi; Kenward Vong; Karine Auclair
Journal:  Bioorg Med Chem       Date:  2011-03-04       Impact factor: 3.641

3.  A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites.

Authors:  Christina Spry; Christina L L Chai; Kiaran Kirk; Kevin J Saliba
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

4.  Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.

Authors:  Vanessa M Howieson; Elisa Tran; Annabelle Hoegl; Han Ling Fam; Jonathan Fu; Kate Sivonen; Xiao Xuan Li; Karine Auclair; Kevin J Saliba
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

5.  Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

Authors:  Marianne de Villiers; Cristiano Macuamule; Christina Spry; Yoo-Min Hyun; Erick Strauss; Kevin J Saliba
Journal:  ACS Med Chem Lett       Date:  2013-06-17       Impact factor: 4.345

6.  The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

Authors:  Renier van der Westhuyzen; Justin C Hammons; Jordan L Meier; Samira Dahesh; Wessel J A Moolman; Stephen C Pelly; Victor Nizet; Michael D Burkart; Erick Strauss
Journal:  Chem Biol       Date:  2012-05-25

7.  Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.

Authors:  Emelia Awuah; Eric Ma; Annabelle Hoegl; Kenward Vong; Eric Habib; Karine Auclair
Journal:  Bioorg Med Chem       Date:  2014-04-24       Impact factor: 3.641

8.  Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

Authors:  Patrick A M Jansen; Pedro H H Hermkens; Patrick L J M Zeeuwen; Peter N M Botman; Richard H Blaauw; Peter Burghout; Peter M van Galen; Johan W Mouton; Floris P J T Rutjes; Joost Schalkwijk
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

9.  Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.

Authors:  Anthony E Choudhry; Tracy L Mandichak; John P Broskey; Richard W Egolf; Cynthia Kinsland; Tadhg P Begley; Mark A Seefeld; Thomas W Ku; James R Brown; Magdalena Zalacain; Kapila Ratnam
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

10.  Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis.

Authors:  Jacob Thomas; John E Cronan
Journal:  Antimicrob Agents Chemother       Date:  2010-01-04       Impact factor: 5.191
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