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Literature DB >> 20047918

Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis.

Abstract

Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.

Entities: Chemical Gene

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Year: 2010 PMID： 20047918 PMCID： PMC2826004 DOI： 10.1128/AAC.01473-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

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12 in total

1. Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity.

Authors: Annabelle Hoegl; Hamed Darabi; Elisa Tran; Emelia Awuah; Eleanor S C Kerdo; Eric Habib; Kevin J Saliba; Karine Auclair
Journal: Bioorg Med Chem Lett Date: 2014-06-18 Impact factor: 2.823

2. Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.

Authors: T Olukayode Akinnusi; Kenward Vong; Karine Auclair
Journal: Bioorg Med Chem Date: 2011-03-04 Impact factor: 3.641

3. Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis.

Authors: John Mosior; Ronnie Bourland; Shivatheja Soma; Carl Nathan; James Sacchettini
Journal: Protein Sci Date: 2020-01-20 Impact factor: 6.725

4. Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.

Authors: Carl J Balibar; Micah F Hollis-Symynkywicz; Jianshi Tao
Journal: J Bacteriol Date: 2011-05-06 Impact factor: 3.490

5. The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

Authors: Renier van der Westhuyzen; Justin C Hammons; Jordan L Meier; Samira Dahesh; Wessel J A Moolman; Stephen C Pelly; Victor Nizet; Michael D Burkart; Erick Strauss
Journal: Chem Biol Date: 2012-05-25

6. Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.

Authors: Emelia Awuah; Eric Ma; Annabelle Hoegl; Kenward Vong; Eric Habib; Karine Auclair
Journal: Bioorg Med Chem Date: 2014-04-24 Impact factor: 3.641

7. Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis.

Authors: Lyanne Gómez-Rodríguez; Pamela J Schultz; Giselle Tamayo-Castillo; Garry D Dotson; David H Sherman; Ashootosh Tripathi
Journal: Tetrahedron Lett Date: 2019-12-02 Impact factor: 2.415

8. Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

Authors: Patrick A M Jansen; Pedro H H Hermkens; Patrick L J M Zeeuwen; Peter N M Botman; Richard H Blaauw; Peter Burghout; Peter M van Galen; Johan W Mouton; Floris P J T Rutjes; Joost Schalkwijk
Journal: Antimicrob Agents Chemother Date: 2013-07-22 Impact factor: 5.191

9. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Authors: Christina Spry; Cristiano Macuamule; Zhiyang Lin; Kristopher G Virga; Richard E Lee; Erick Strauss; Kevin J Saliba
Journal: PLoS One Date: 2013-02-06 Impact factor: 3.240

10. A cross-metathesis approach to novel pantothenamide derivatives.

Authors: Jinming Guan; Matthew Hachey; Lekha Puri; Vanessa Howieson; Kevin J Saliba; Karine Auclair
Journal: Beilstein J Org Chem Date: 2016-05-13 Impact factor: 2.883