Literature DB >> 12760898

Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.

Anthony E Choudhry1, Tracy L Mandichak, John P Broskey, Richard W Egolf, Cynthia Kinsland, Tadhg P Begley, Mark A Seefeld, Thomas W Ku, James R Brown, Magdalena Zalacain, Kapila Ratnam.   

Abstract

Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.

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Year:  2003        PMID： 12760898      PMCID： PMC155856          DOI： 10.1128/AAC.47.6.2051-2055.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.

Authors:  E Strauss; C Kinsland; Y Ge; F W McLafferty; T P Begley
Journal:  J Biol Chem       Date:  2001-03-13       Impact factor: 5.157

Review 2.  The biosynthesis of coenzyme A in bacteria.

Authors:  T P Begley; C Kinsland; E Strauss
Journal:  Vitam Horm       Date:  2001       Impact factor: 3.421

3.  fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster.

Authors:  K Afshar; P Gönczy; S DiNardo; S A Wasserman
Journal:  Genetics       Date:  2001-03       Impact factor: 4.562

4.  Pantothenate kinase regulation of the intracellular concentration of coenzyme A.

Authors:  C O Rock; R B Calder; M A Karim; S Jackowski
Journal:  J Biol Chem       Date:  2000-01-14       Impact factor: 5.157

5.  Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors:  M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
Journal:  Lancet       Date:  2001-04-21       Impact factor: 79.321

6.  Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis.

Authors:  Timothy D Read; Steven L Salzberg; Mihai Pop; Martin Shumway; Lowell Umayam; Lingxia Jiang; Erik Holtzapple; Joseph D Busch; Kimothy L Smith; James M Schupp; Daniel Solomon; Paul Keim; Claire M Fraser
Journal:  Science       Date:  2002-05-09       Impact factor: 47.728

7.  Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12.

Authors:  P Mishra; P K Park; D G Drueckhammer
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

8.  Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis.

Authors:  T Kupke; M Uebele; D Schmid; G Jung; M Blaesse; S Steinbacher
Journal:  J Biol Chem       Date:  2000-10-13       Impact factor: 5.157

9.  Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics.

Authors:  Matthew Daugherty; Boris Polanuyer; Michael Farrell; Michael Scholle; Athanasios Lykidis; Valerie de Crécy-Lagard; Andrei Osterman
Journal:  J Biol Chem       Date:  2002-03-28       Impact factor: 5.157

10.  Discovery of a novel and potent class of FabI-directed antibacterial agents.

Authors:  David J Payne; William H Miller; Valerie Berry; John Brosky; Walter J Burgess; Emile Chen; Walter E DeWolf; Andrew P Fosberry; Rebecca Greenwood; Martha S Head; Dirk A Heerding; Cheryl A Janson; Deborah D Jaworski; Paul M Keller; Peter J Manley; Terrance D Moore; Kenneth A Newlander; Stewart Pearson; Brian J Polizzi; Xiayang Qiu; Stephen F Rittenhouse; Courtney Slater-Radosti; Kevin L Salyers; Mark A Seefeld; Martin G Smyth; Dennis T Takata; Irene N Uzinskas; Kalindi Vaidya; Nicola G Wallis; Scott B Winram; Catherine C K Yuan; William F Huffman
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191
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  25 in total

1.  Identification of group A Streptococcus antigenic determinants upregulated in vivo.

Authors:  Kowthar Y Salim; Dennis G Cvitkovitch; Peter Chang; Darrin J Bast; Martin Handfield; Jeffrey D Hillman; Joyce C S de Azavedo
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase.

Authors:  Xuxu Yan; T Olukayode Akinnusi; Aaron T Larsen; Karine Auclair
Journal:  Org Biomol Chem       Date:  2011-01-12       Impact factor: 3.876

Review 3.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

4.  Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity.

Authors:  Annabelle Hoegl; Hamed Darabi; Elisa Tran; Emelia Awuah; Eleanor S C Kerdo; Eric Habib; Kevin J Saliba; Karine Auclair
Journal:  Bioorg Med Chem Lett       Date:  2014-06-18       Impact factor: 2.823

5.  Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.

Authors:  T Olukayode Akinnusi; Kenward Vong; Karine Auclair
Journal:  Bioorg Med Chem       Date:  2011-03-04       Impact factor: 3.641

6.  Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

Authors:  Marianne de Villiers; Cristiano Macuamule; Christina Spry; Yoo-Min Hyun; Erick Strauss; Kevin J Saliba
Journal:  ACS Med Chem Lett       Date:  2013-06-17       Impact factor: 4.345

7.  Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.

Authors:  Carl J Balibar; Micah F Hollis-Symynkywicz; Jianshi Tao
Journal:  J Bacteriol       Date:  2011-05-06       Impact factor: 3.490

8.  Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase .

Authors:  James B Thoden; Hazel M Holden; Hanumantharao Paritala; Steven M Firestine
Journal:  Biochemistry       Date:  2010-02-02       Impact factor: 3.162

9.  Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.

Authors:  Patrick A M Jansen; Pedro H H Hermkens; Patrick L J M Zeeuwen; Peter N M Botman; Richard H Blaauw; Peter Burghout; Peter M van Galen; Johan W Mouton; Floris P J T Rutjes; Joost Schalkwijk
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

10.  Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.

Authors:  Masakazu Takagi; Hideyuki Tamaki; Yukiko Miyamoto; Roberta Leonardi; Satoshi Hanada; Suzanne Jackowski; Shigeru Chohnan
Journal:  J Bacteriol       Date:  2010-01       Impact factor: 3.490
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