Literature DB >> 490532

Adamantylthiourea derivatives as antiviral agents.

J W Tilley, P Levitan, M J Kramer.   

Abstract

A series of nine 3-substituted 1-adamantylthioureas was prepared and tested for antiviral activity against influenza A2/Asian/J305 virus in vivo and in vitro. Protective dose 50 values were calculated for three of the compounds. One of these compounds, 7, has antiviral activity which compares favorably with that of amantadine.

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Year:  1979        PMID： 490532     DOI： 10.1021/jm00194a025

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

Review 1.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

2.  Synthesis and Structural Characterization of 1-Arylimidazole-2-thiones and N,N'-Aryldiethoxyethylthioureas with Electronically Diverse Substituents: A Manifold of Hydrogen Bonding Networks.

Authors:  Joshua H Palmer; Gerard Parkin
Journal:  New J Chem       Date:  2014-09-01       Impact factor: 3.591

3.  Synthesis and Bioactivity of Hydrazide-Hydrazones with the 1-Adamantyl-Carbonyl Moiety.

Authors:  Van Hien Pham; Thi Phuong Dung Phan; Dinh Chau Phan; Binh Duong Vu
Journal:  Molecules       Date:  2019-11-05       Impact factor: 4.411

4.  Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.

Authors:  María D Duque; Pelayo Camps; Lenuta Profire; Silvia Montaner; Santiago Vázquez; Francesc X Sureda; Jordi Mallol; Marta López-Querol; Lieve Naesens; Erik De Clercq; S Radhika Prathalingam; John M Kelly
Journal:  Bioorg Med Chem       Date:  2009-02-13       Impact factor: 3.641

5.  Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols.

Authors:  Ebtehal S Al-Abdullah; Hanadi H Asiri; Siham Lahsasni; Elsayed E Habib; Tarek M Ibrahim; Ali A El-Emam
Journal:  Drug Des Devel Ther       Date:  2014-05-12       Impact factor: 4.162

6.  Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.

Authors:  Pelayo Camps; María D Duque; Santiago Vázquez; Lieve Naesens; Erik De Clercq; Francesc X Sureda; Marta López-Querol; Antoni Camins; Mercè Pallàs; S Radhika Prathalingam; John M Kelly; Vanessa Romero; Dolores Ivorra; Diego Cortés
Journal:  Bioorg Med Chem       Date:  2008-10-17       Impact factor: 3.641

7.  Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons.

Authors:  Van Hien Pham; Thi Phuong Dung Phan; Dinh Chau Phan; Binh Duong Vu
Journal:  Molecules       Date:  2020-01-13       Impact factor: 4.411
  7 in total

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