| Literature DB >> 4144962 |
D J Williams, R P Clark, B R Rabin.
Abstract
The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.Entities:
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Year: 1973 PMID： 4144962 PMCID： PMC2008791 DOI： 10.1038/bjc.1973.35
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640