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Literature DB >> 4886300

Mutations to spectinomycin resistance which alleviate the restriction of an amber suppressor by streptomycin resistance.

Abstract

Unlike mutations to streptomycin resistance, which restrict the function of an SU II amber suppressor, mutations to spectinomycin resistance have no restrictive effect. Furthermore, mutations to spectinomycin resistance counteract the restrictive action of streptomycin-resistant mutations when combined in a single strain. The mutations to drug resistance, singly or in combination, do not themselves lead to any detectable suppressor activity. The effects on SU II are interpreted in terms of interactions between ribosomal elements.

Entities: Chemical

Mesh：

Substances：
Streptomycin

Year: 1969 PMID： 4886300 PMCID： PMC249780 DOI： 10.1128/jb.97.2.940-943.1969

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

21 in total

1. A change from nonsense to sense in the genetic code.

Authors: S BENZER; S P CHAMPE
Journal: Proc Natl Acad Sci U S A Date: 1962-07-15 Impact factor: 11.205

2. Mutation to extended host range and the occurrence of phenotypic mixing in the temperate coliphage lambda.

Authors: R K APPLEYARD; J F MCGREGOR; K M BAIRD
Journal: Virology Date: 1956-08 Impact factor: 3.616

3. Induction of mutations to streptomycin and spectinomycin resistance in Escherichia coli by N-methyl-N'-nitroso-N-nitroguanidine and acridine half-mustard ICR-191.

Authors: L Silengo; D Schlessinger; G Mangiarotti; D Apirion
Journal: Mutat Res Date: 1967 Sep-Oct Impact factor: 2.433

Mutations to spectinomycin resistance which alleviate the restriction of an amber suppressor by streptomycin resistance.

1. A change from nonsense to sense in the genetic code.

2. Mutation to extended host range and the occurrence of phenotypic mixing in the temperate coliphage lambda.

3. Induction of mutations to streptomycin and spectinomycin resistance in Escherichia coli by N-methyl-N'-nitroso-N-nitroguanidine and acridine half-mustard ICR-191.

4. Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli.

5. Su-II-specific restriction of amber suppression by mutation to streptomycin resistance.

6. The loss of phenotypic suppression in streptomycin-resistant mutants.

7. Suppressor genes for nonsense mutations. I. The Su-1, Su-2 and Su-3 genes of Escherichia coli.

8. Effect of mutation to streptomycin resistance on amber suppressor genes.

9. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor.

10. Improvements in epoxy resin embedding methods.

1. Effect of different mutations in ribosomal protein S5 of Escherichia coli on translational fidelity.

2. Bacterial ribosome.

3. Ribosomal proteins involved in the suppression of streptomycin dependence in Escherichia coli.

4. Phenotypic suppression by streptomycin of amber mutants in the ribonucleic Acid bacteriophage coat protein cistron.

5. Sucrose-dependent spectinomycin-resistant mutants of Escherichia coli.

6. "Phospholipids of virus-induced membranes in cytoplasm of Escherichia coli.

7. Genetic analysis of a streptomycin-resistant oligosporogenous Bacillus subtilis mutant.

8. Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli.

9. Revertants of a streptomycin-resistant, oligosporogenous mutant of Bacillus subtilis.

10. Sensitivity and Resistance to Spectinomycin in Escherichia coli.