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Literature DB >> 6193099

Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli.

Abstract

A spectinomycin resistance mutation was isolated in an Escherichia coli rRNA operon (rrnH) located on a multicopy plasmid. Cell-free protein-synthesizing extracts made from cells containing the plasmid were partially resistant to spectinomycin. Although spectinomycin is an aminoglycoside antibiotic, the mutation did not confer resistance to any other aminoglycoside antibiotic tested.

Entities: Chemical Species

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Year: 1983 PMID： 6193099 PMCID： PMC217790 DOI： 10.1128/jb.155.3.989-994.1983

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

31 in total

1. Mechanism of kasugamycin resistance in Escherichia coli.

Authors: T L Helser; J E Davies; J E Dahlberg
Journal: Nat New Biol Date: 1972-01-05

2. Ribosomes from Escherichia coli merodiplods heterozygous for resistance to streptomycin and to spectinomycin.

Authors: P F Sparling; J Modolell; Y Takeda; B D Davis
Journal: J Mol Biol Date: 1968-11-14 Impact factor: 5.469

3. Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli.

Authors: P Anderson; J Davies; B D Davis
Journal: J Mol Biol Date: 1967-10-14 Impact factor: 5.469

4. Misreading of RNA codewords induced by aminoglycoside antibiotics.

Authors: J Davies; L Gorini; B D Davis
Journal: Mol Pharmacol Date: 1965-07 Impact factor: 4.436

5. Altered ribosomes in antibiotic-resistant mutants of E. coli.

Authors: A Bollen; T Helser; T Yamada; J Davies
Journal: Cold Spring Harb Symp Quant Biol Date: 1969

6. Ribosomal mutations affecting efficiency of amber suppression.

Authors: P Strigini; L Gorini
Journal: J Mol Biol Date: 1970-02-14 Impact factor: 5.469

7. Mutations to spectinomycin resistance which alleviate the restriction of an amber suppressor by streptomycin resistance.

Authors: M Kuwano; H Endo; Y Ohnishi
Journal: J Bacteriol Date: 1969-02 Impact factor: 3.490

8. A further study of misreading of codons induced by streptomycin and neomycin using ribopolynucleotides containing two nucleotides in alternating sequence as templates.

Authors: J Davies; D S Jones; H G Khorana
Journal: J Mol Biol Date: 1966-06 Impact factor: 5.469

9. Streptomycin action: greater inhibition of Escherichia coli ribosome function with exogenous than with endogenous messenger ribonucleic acid.

Authors: L Luzzatto; D Apirion; D Schlessinger
Journal: J Bacteriol Date: 1969-07 Impact factor: 3.490

10. Inhibition of protein synthesis by spectinomycin.

Authors: J Davies; P Anderson; B D Davis
Journal: Science Date: 1965-09-03 Impact factor: 47.728

14 in total

1. Adaptation of aquatic microbial communities to hg stress.

Authors: T Barkay
Journal: Appl Environ Microbiol Date: 1987-12 Impact factor: 4.792

2. Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis.

Authors: P A Skeggs; J Thompson; E Cundliffe
Journal: Mol Gen Genet Date: 1985

3. Unbalanced rRNA gene dosage and its effects on rRNA and ribosomal-protein synthesis.

Authors: R J Siehnel; E A Morgan
Journal: J Bacteriol Date: 1985-08 Impact factor: 3.490

4. Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea.

Authors: W Piendl; A Böck; E Cundliffe
Journal: Mol Gen Genet Date: 1984