Literature DB >> 4886117

Repression by glucose of acetohydroxy acid synthetase in Escherichia coli B.

M B Coukell, W J Polglase.   

Abstract

Acetolactate formation in Escherichia coli B results from the activity of a single system, acetohydroxy acid synthetase, which has a pH optimum of 8.0 and is sensitive to end-product inhibition by l-valine. Acetohydroxy acid synthetase was found to be subject to catabolite repression, and the nature and concentration of the carbon source had a greater effect on the formation of the enzyme than had the known end products (valine, isoleucine, leucine and pantothenate) of the biosynthetic pathways of which this enzyme is a member. The results suggest that acetohydroxy acid synthetase may play an amphibolic role in E. coli B.

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Year:  1969        PMID： 4886117      PMCID： PMC1187508          DOI： 10.1042/bj1110273

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes.

Authors:  Y S HALPERN; H E UMBARGER
Journal:  J Biol Chem       Date:  1959-12       Impact factor: 5.157

2.  BIOSYNTHESIS OF VALINE AND ISOLEUCINE, VI. ENZYME REPRESSION IN SALMONELLA.

Authors:  F B Armstrong; M L Gordon; R P Wagner
Journal:  Proc Natl Acad Sci U S A       Date:  1963-03       Impact factor: 11.205

3.  The influence of the presence of glucose during growth on the enzymic activities of Escherichia coli: comparison of the effect with that produced by fermentation acids.

Authors:  H M Epps; E F Gale
Journal:  Biochem J       Date:  1942-09       Impact factor: 3.857

4.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

5.  Regulation of acetohydroxy and synthetase in streptomycin-dependent Escherichia coli.

Authors:  W J Polglase
Journal:  Can J Biochem       Date:  1966-05

6.  Characterization and properties of acetohydroxy acid synthetase of streptomycin-dependent Escherichia coli.

Authors:  I D Desai; W J Polglase
Journal:  Biochim Biophys Acta       Date:  1965-10-25

7.  Isoleucine and valine metabolism in Escherichia coli. VII. A negative feedback mechanism controlling isoleucine biosynthesis.

Authors:  H E UMBARGER; B BROWN
Journal:  J Biol Chem       Date:  1958-08       Impact factor: 5.157

8.  ENZYMATIC ACTIVITIES OF STREPTOMYCIN-DEPENDENT ESCHERICHIA COLI IN RELATION TO VALINE FORMATION.

Authors:  P D BRAGG; W J POLGLASE
Journal:  J Bacteriol       Date:  1964-11       Impact factor: 3.490

9.  Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes.

Authors:  R S Hanson; D P Cox
Journal:  J Bacteriol       Date:  1967-06       Impact factor: 3.490

10.  REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES.

Authors:  T RAMAKRISHNAN; E A ADELBERG
Journal:  J Bacteriol       Date:  1965-03       Impact factor: 3.490
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  5 in total

1.  Biosynthesis of branched-chain amino acids in yeast: effect of carbon source on leucine biosynthetic enzymes.

Authors:  H D Brown; T Satyanarayana; H E Umbarger
Journal:  J Bacteriol       Date:  1975-03       Impact factor: 3.490

2.  Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: properties of acetohydroxy acid synthetase.

Authors:  R A McDonald; T Satyanarayana; J G Kaplan
Journal:  J Bacteriol       Date:  1973-04       Impact factor: 3.490

3.  Regulation of cyclic AMP of the ilvB-encoded biosynthetic acetohydroxy acid synthase in Escherichia coli K-12.

Authors:  A Sutton; M Freundlich
Journal:  Mol Gen Genet       Date:  1980-04

4.  Regulation of acetohydroxy acid synthase in streptomycin-dependent Escherichia coli.

Authors:  K J Whitlow; W J Polglase
Journal:  J Bacteriol       Date:  1975-01       Impact factor: 3.490

5.  Relaxation of catabolite repression in streptomycin-dependent Escherichia coli.

Authors:  M B Coukell; W J Polglase
Journal:  Biochem J       Date:  1969-02       Impact factor: 3.857
  5 in total

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