Literature DB >> 6247617

Regulation of cyclic AMP of the ilvB-encoded biosynthetic acetohydroxy acid synthase in Escherichia coli K-12.

A Sutton, M Freundlich.   

Abstract

The biosynthetic acetohydroxy acid synthase activities of E. coli K 12 are encoded by three genetic loci namely, ilvB (acetohydroxy acid synthase I), ilvG (acetohydroxy acid synthase II) and ilvHI (acetohydroxy acid synthase III). The previously reported involvement of cyclic AMP in the regulation of the biosynthetic acetohydroxy acid synthase isozymes in E. coli K-12 was found to be due to the effect of this nucleotide on the expression of ilvB. Cyclic AMP had no effect on acetohydroxy acid synthase activity in strains lacking wild-type ilvB activity but containing the remaining isozymes. Very little activity of acetohydroxy acid synthase coded for by ilvV was found when ppGpp and cyclic AMP were severely limited. Addition of cyclic AMP under these conditions increased ilvB expression 24-fold. The data suggest that in addition to multivalent repression and ppGpp, cyclic AMP plays a major role in the regulation of the ilvB biosynthetic operon.

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Year:  1980        PMID： 6247617     DOI： 10.1007/bf00267227

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  26 in total

1.  Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes.

Authors:  Y S HALPERN; H E UMBARGER
Journal:  J Biol Chem       Date:  1959-12       Impact factor: 5.157

2.  Mutants of Escherichia coli requiring methionine or vitamin B12.

Authors:  B D DAVIS; E S MINGIOLI
Journal:  J Bacteriol       Date:  1950-07       Impact factor: 3.490

3.  Cyclic AMP can replace the relA-dependent requirement for derepression of acetohydroxy acid synthase in E. coli K-12.

Authors:  M Freundlich
Journal:  Cell       Date:  1977-12       Impact factor: 41.582

4.  Metabolic interlock between the acetolactate synthase isoenzymes and lysine biosynthesis in Escherichia coli K-12.

Authors:  M De Felice; J Guardiola; W Schreil; M Levinthal; M Iaccarino
Journal:  Mol Gen Genet       Date:  1977-11-04

5.  The acetolactate synthase isoenzymes of Escherichia coli K-12.

Authors:  J Guardiola; M De Felice; A Lamberti; M Iaccarino
Journal:  Mol Gen Genet       Date:  1977-11-04

6.  Mutant of Escherichia coli K-12 missing acetolactate synthase activity.

Authors:  J Guardiola; M De Felice; M Iaccarino
Journal:  J Bacteriol       Date:  1974-10       Impact factor: 3.490

7.  Structural genes for a newly recognized acetolactate synthase in Escherichia coli K-12.

Authors:  M De Felice; J Guardiola; B Esposito; M Iaccarino
Journal:  J Bacteriol       Date:  1974-12       Impact factor: 3.490

8.  Relaxation of catabolite repression and loss of valine sensitivity in Escherichia coli K-12.

Authors:  K J Whitlow; W J Polglase
Journal:  FEBS Lett       Date:  1974-07-01       Impact factor: 4.124

9.  Derepressed levels of the isoleucine-valine and leucine enzymes in his T 1504, a strain of Salmonella typhimurium with altered leucine transfer ribonucleic acid.

Authors:  A A Rizzino; R S Bresalier; M Freundlich
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490

10.  REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. 3. MAP ORDER OF THE STRUCTURAL GENES AND OPERATOR GENES.

Authors:  T RAMAKRISHNAN; E A ADELBERG
Journal:  J Bacteriol       Date:  1965-03       Impact factor: 3.490
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  26 in total

1.  Evidence for cAMP-mediated control of isoleucyl-tRNA synthetase formation in Escherichia coli K-12.

Authors:  A L Williams; R S Barnett
Journal:  Arch Microbiol       Date:  1985-07       Impact factor: 2.552

2.  The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12.

Authors:  R P Lawther; R C Wek; J M Lopes; R Pereira; B E Taillon; G W Hatfield
Journal:  Nucleic Acids Res       Date:  1987-03-11       Impact factor: 16.971

3.  Comparison of DeltarelA strains of Escherichia coli and Salmonella enterica serovar Typhimurium suggests a role for ppGpp in attenuation regulation of branched-chain amino acid biosynthesis.

Authors:  K Tedin; F Norel
Journal:  J Bacteriol       Date:  2001-11       Impact factor: 3.490

4.  Interaction of cyclic AMP receptor protein with the ilvB biosynthetic operon in E. coli.

Authors:  P Friden; P Tsui; K Okamoto; M Freundlich
Journal:  Nucleic Acids Res       Date:  1984-11-12       Impact factor: 16.971

5.  ilvB-encoded acetolactate synthase is resistant to the herbicide sulfometuron methyl.

Authors:  R A LaRossa; D R Smulski
Journal:  J Bacteriol       Date:  1984-10       Impact factor: 3.490

6.  Attenuation of the ilvB operon by amino acids reflecting substrates or products of the ilvB gene product.

Authors:  C A Hauser; G W Hatfield
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

7.  Starvation for ilvB operon leader amino acids other than leucine or valine does not increase acetohydroxy acid synthase activity in Escherichia coli.

Authors:  P Tsui; M Freundlich
Journal:  J Bacteriol       Date:  1985-06       Impact factor: 3.490

Review 8.  The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.

Authors:  J M Calvo; R G Matthews
Journal:  Microbiol Rev       Date:  1994-09

9.  Acetohydroxy acid synthase I is required for isoleucine and valine biosynthesis by Salmonella typhimurium LT2 during growth on acetate or long-chain fatty acids.

Authors:  F E Dailey; J E Cronan; S R Maloy
Journal:  J Bacteriol       Date:  1987-02       Impact factor: 3.490

10.  Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria.

Authors:  Z Barak; D M Chipman; N Gollop
Journal:  J Bacteriol       Date:  1987-08       Impact factor: 3.490
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