Literature DB >> 488300

DNA synthesis in the pituitary gland of the rat: effect of sulpiride and clomiphene.

J A Burdman, I Szijan, G A Jahn, G Machiavelli, L E Kalbermann.   

Abstract

Sulpiride administration to rats releases prolactin and increases DNA replication in the anterior pituitary gland. Clomiphene prevents the stimulation of DNA synthesis produced by sulpiride, but does not affect prolactin release from the gland. These findings suggest that the intracellular prolactin content of the anterior pituitary gland plays a role in the regulation of DNA synthesis through a mechanism mediated by oestrogens.

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Year:  1979        PMID： 488300     DOI： 10.1007/bf01963324

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells.

Authors:  H M Lloyd; J D Meares; J Jacobi
Journal:  Nature       Date:  1975-06-05       Impact factor: 49.962

2.  EFFECTS OF CLOMIPHENE ON THE PHYSIOLOGY OF REPRODUCTION IN THE RAT. II. ITS OESTROGENIC AND ANTIOESTROGENIC ACTIONS.

Authors:  S ROY; R B GREENBLATT; V B MAHESH
Journal:  Acta Endocrinol (Copenh)       Date:  1964-12

3.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

4.  Radioimmunoassay for rat prolactin.

Authors:  G D Niswender; C L Chen; A R Midgley; J Meites; S Ellis
Journal:  Proc Soc Exp Biol Med       Date:  1969-03

5.  Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats.

Authors:  F Naftolin; K J Ryan; Z Petro
Journal:  Endocrinology       Date:  1972-01       Impact factor: 4.736

6.  Some effects of certain naturally occurring oestrogens on the anterior pituitary glands of rats.

Authors:  E Stevens; J E Helfenstein
Journal:  Nature       Date:  1966-08-20       Impact factor: 49.962

7.  Acute and chronic effects of sulpride on serum prolactin and gonadotropin levels in castrated male rats (38581).

Authors:  L Debeljuk; R Rozados; H Daskal; V Velez; A M Mancini
Journal:  Proc Soc Exp Biol Med       Date:  1975-02

8.  Cell proliferation in the rat pituitary gland: a mechanism of control in prolactin cells.

Authors:  L E Kalbermann; I Szijan; J A Burdman
Journal:  Experientia       Date:  1979-05-15
  8 in total

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