Literature DB >> 3783148

Neuropeptide Y enhances the inhibitory effects of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat.

M Martire, K Fuxe, G Pistritto, P Preziosi, L F Agnati.   

Abstract

In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of the alpha 2-adrenergic agonist clonidine (0.1 microM) on potassium (15 mM K+) induced 3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. The effect of NPY was detectable at low concentrations (1 nM) and was not dose-dependent. Neuropeptide Y alone produced no significant effects on 3H-NA release. The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynaptic alpha 2-adrenoreceptor function to inhibit 3H-NA release.

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Year:  1986        PMID： 3783148     DOI： 10.1007/bf01243364

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  32 in total

1.  Morphofunctional studies on the neuropeptide Y/adrenaline costoring terminal systems in the dorsal cardiovascular region of the medulla oblongata. Focus on receptor-receptor interactions in cotransmission.

Authors:  K Fuxe; L F Agnati; A Härfstrand; A M Janson; A Neumeyer; K Andersson; M Ruggeri; M Zoli; M Goldstein
Journal:  Prog Brain Res       Date:  1986       Impact factor: 2.453

2.  Evidence for a central noradrenaline receptor stimulation by clonidine.

Authors:  N E Andén; H Corrodi; K Fuxe; B Hökfelt; T Hökfelt; C Rydin; T Svensson
Journal:  Life Sci       Date:  1970-05-01       Impact factor: 5.037

3.  Neuroanatomical methods for the quantitative evaluation of coexistence of transmitters in nerve cells. Analysis of the ACTH- and beta-endorphin immunoreactive nerve cell bodies of the mediobasal hypothalamus of the rat.

Authors:  L F Agnati; K Fuxe; V Locatelli; F Benfenati; I Zini; A E Panerai; M F El Etreby; T Hökfelt
Journal:  J Neurosci Methods       Date:  1982-03       Impact factor: 2.390

4.  Studies on neuropeptide-Y catecholamine interactions in central cardiovascular regulation in the alpha-chloralose anaesthetized rat. Evidence for a possible new way of activating the alpha-2 adrenergic transmission line.

Authors:  A Härfstrand; K Fuxe; L F Agnati; D Ganten; P Eneroth; K Tatemoto; V Mutt
Journal:  Clin Exp Hypertens A       Date:  1984

Review 5.  Presynaptic receptors.

Authors:  K Starke
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

6.  Neuropeptide Y in vitro selectivity increases the number of alpha 2-adrenergic binding sites in membranes of the medulla oblongata of the rat.

Authors:  L F Agnati; K Fuxe; F Benfenati; N Battistini; A Härfstrand; K Tatemoto; T Hökfelt; V Mutt
Journal:  Acta Physiol Scand       Date:  1983-07

7.  Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.

Authors:  K Tatemoto; M Carlquist; V Mutt
Journal:  Nature       Date:  1982-04-15       Impact factor: 49.962

8.  Evidence for the existence of receptor--receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides.

Authors:  K Fuxe; L F Agnati; F Benfenati; M Celani; I Zini; M Zoli; V Mutt
Journal:  J Neural Transm Suppl       Date:  1983

9.  On the functional role of coexistence of 5-HT and substance P in bulbospinal 5-HT neurons. Substance P reduces affinity and increases density of 3H-5-HT binding sites.

Authors:  L F Agnati; K Fuxe; F Benfenati; I Zini; T Hökfelt
Journal:  Acta Physiol Scand       Date:  1983-02

10.  Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens.

Authors:  J M Allen; T E Adrian; K Tatemoto; J M Polak; J Hughes; S R Bloom
Journal:  Neuropeptides       Date:  1982-12       Impact factor: 3.286
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  5 in total

1.  Reduced inhibitory effects of clonidine and neuropeptide Y on 3H-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat.

Authors:  M Martire; K Fuxe; G Pistritto; P Preziosi; L F Agnati
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

2.  Reciprocal interactions between alpha 2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarius of the rat. A biochemic and autoradiographic analysis.

Authors:  A Härfstrand; K Fuxe; L Agnati; B Fredholm
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

3.  Neuropeptide Y increases the inhibitory effects of clonidine on potassium evoked 3H-noradrenaline but not 3H-5-hydroxytryptamine release from synaptosomes of the hypothalamus and the frontoparietal cortex of the male Sprague-Dawley rat.

Authors:  M Martire; K Fuxe; G Pistritto; P Preziosi; L F Agnati
Journal:  J Neural Transm Gen Sect       Date:  1989

4.  Modulation of cholinergic neurotransmission in guinea-pig trachea by neuropeptide Y.

Authors:  C D Stretton; P J Barnes
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

5.  Enhanced inhibitory control by neuropeptide Y Y5 receptor blockade in rats.

Authors:  A Bari; A Dec; A W Lee; J Lee; D Song; E Dale; J Peterson; S Zorn; X Huang; B Campbell; T W Robbins; A R West
Journal:  Psychopharmacology (Berl)       Date:  2014-09-07       Impact factor: 4.530
  5 in total

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