Literature DB >> 487651

Corticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes.

D A Cooper, M Duckett, V Petts, R Penny.   

Abstract

The effects of the addition in vitro of corticosteroid on pokeweed mitogen (PWM) induced Ig synthesis by human peripheral blood lymphocytes were studied. IgG in supernatants produced under standardized culture conditions was measured by double antibody radioimmunoassay. The addition of 10(-6)M prednisolone caused a remarkable enhancement of PWM-stimulated IgG synthesis beginning at day 4 of culture and increasing at a faster rate than that in cultures with PWM alone. 10(-6)M prednisolone resulted in a geometric mean enhancement of 5.6-fold of PWM-stimulated IgG synthesis in all twenty-five normal controls studied. This enhancement occurred up to 3 days after the addition of PWM. 10(-6)M and 10(-5)M prednisolone resulted in significantly greater enhancement of PWM-stimulated IgG synthesis than 10(-7)M prednisolone. Hydrocortisone, prednisolone, methylprednisolone, betamethasone and dexamethasone at 10(-6)M were all equally effective in the enhancement of PWM-induced IgG synthesis.

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Year:  1979        PMID： 487651      PMCID： PMC1537658     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

1.  T-cell regulation of immunoglobulin synthesis and proliferation in pokeweed (Pa-1)-stimulated human lymphocyte cultures.

Authors:  G Janossy; E Gomez de la Concha; A Luquetti; M J Snajdr; M J Waxdal; T A Platts-Mills
Journal:  Scand J Immunol       Date:  1977       Impact factor: 3.487

2.  Effect of hydrocortisone on immunoglobulin synthesis and secretion by human peripheral lymphocytes in vitro.

Authors:  R S Smith; N A Sherman; E Middleton
Journal:  Int Arch Allergy Appl Immunol       Date:  1972

3.  Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity.

Authors:  T A Waldmann; R M Blaese; S Broder; R S Krakauer
Journal:  Ann Intern Med       Date:  1978-02       Impact factor: 25.391

4.  Differentiation of human peripheral blood B lymphocytes.

Authors:  Y S Choi; R A Good
Journal:  Immunology       Date:  1977-12       Impact factor: 7.397

5.  The T cell dependence of B cell differentiation induced by pokeweed mitogen.

Authors:  R G Keightley; M D Cooper; A R Lawton
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422

6.  Effect of prednisone treatment on the human immune response to keyhole limpet hemocyanin.

Authors:  M Tuchinda; R W Newcomb; B L DeVald
Journal:  Int Arch Allergy Appl Immunol       Date:  1972

7.  Activation of human B lymphocytes. IV. Regulatory effects of corticosteroids on the triggering signal in the plaque-forming cell response of human peripheral blood B lymphocytes to polyclonal activation.

Authors:  A S Fauci; K R Pratt; G Whalen
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

8.  The effect of acute and prolonged administration of prednisolone and ACTH on lymphocyte subpopulations.

Authors:  D A Cooper; V Petts; E Luckhurst; R Penny
Journal:  Clin Exp Immunol       Date:  1977-06       Impact factor: 4.330

9.  IgA and IgA diphtheria antitoxin responses from human tonsil lymphocytes.

Authors:  T A Platts-Mills; K Ishizaka
Journal:  J Immunol       Date:  1975-03       Impact factor: 5.422

10.  THE REQUIREMENT FOR HYDROCORTISONE IN ANTIBODY-FORMING TISSUE CULTIVATED IN SERUM-FREE MEDIUM.

Authors:  C T AMBROSE
Journal:  J Exp Med       Date:  1964-01-01       Impact factor: 14.307
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  9 in total

1.  HLA antigens, phytohemagglutinin stimulation, and corticosteroid response.

Authors:  R P Erickson; L A Heidel; J J Kapur; J M Karolyi; D J Odenheimer; G L Pairitz; J S Schultz; C F Sing
Journal:  Am J Hum Genet       Date:  1985-07       Impact factor: 11.025

2.  Mechanism of action of glucocorticoid-induced immunoglobulin production: II. Requirement for fetal calf serum.

Authors:  S Sierakowski; J S Goodwin
Journal:  Clin Exp Immunol       Date:  1988-01       Impact factor: 4.330

3.  Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation.

Authors:  T R Cupps; T L Gerrard; R J Falkoff; G Whalen; A S Fauci
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

Review 4.  Exercise and the immune response.

Authors:  D Keast; K Cameron; A R Morton
Journal:  Sports Med       Date:  1988-04       Impact factor: 11.136

5.  Disorders of regulatory T cells in patients with selective IgA deficiency and its relationship to associated autoimmune phenomena.

Authors:  E G De la Concha; J L Subiza; G Fontán; D Pascual-Salcedo; J Sequí; A Bootello
Journal:  Clin Exp Immunol       Date:  1982-08       Impact factor: 4.330

6.  Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes.

Authors:  D A Cooper; M Duckett; P Hansen; V Petts; R Penny
Journal:  Clin Exp Immunol       Date:  1981-04       Impact factor: 4.330

7.  Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes. III. Common variable immunodeficiency.

Authors:  D A Cooper; P Hansen; M Duckett; J B Ziegler; R Penny
Journal:  Clin Exp Immunol       Date:  1981-08       Impact factor: 4.330

8.  Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes.

Authors:  C Y Wu; M Sarfati; C Heusser; S Fournier; M Rubio-Trujillo; R Peleman; G Delespesse
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

9.  Modulation of immune responses in stress by Yoga.

Authors:  Sarika Arora; Jayashree Bhattacharjee
Journal:  Int J Yoga       Date:  2008-07
  9 in total

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