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Literature DB >> 304038

Differentiation of human peripheral blood B lymphocytes.

Abstract

Human B-lymphocyte differentiation was studied by measuring the capacity of such cells, isolated from peripheral blood, to synthesize and secrete Ig after pokeweed stimulation. Results show that a maximum incorporation of [3H]-thymidine took place 2 days before the appearance of detectable Ig-secreting cells. On the 7th day after pokeweed stimulation, when Ig synthesis and secretion are at a maximum, [3H]-thymidine uptake was low. Since inhibition of DNA synthesis 3 days after pokeweed stimulation completely prevents the generation of Ig-secreting plasma cells, initial DNA synthesis is apparently essential before Ig-secreting plasma cells can develop in response to pokeweed stimulation.

Entities: Chemical Species

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Year: 1977 PMID： 304038 PMCID： PMC1445553

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

18 in total

1. The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro.

Authors: G Janossy; E Gomez De La Concha; M J Waxdal; T Platts-Mills
Journal: Clin Exp Immunol Date: 1976-10 Impact factor: 4.330

2. Deoxyriboside control and synchronization of mitosis.

Authors: N XEROS
Journal: Nature Date: 1962-05-19 Impact factor: 49.962

Review 3. Electron microscopic and functional aspects of human lymphocyte response to mitogens.

Authors: S D Douglas
Journal: Transplant Rev Date: 1972

Review 4. Elicitation of selective T and B lymphocyte responses by cell surface binding ligands.

Authors: M Greaves; G Janossy
Journal: Transplant Rev Date: 1972

5. Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.

Authors: T A Waldmann; M Durm; S Broder; M Blackman; R M Blaese; W Strober
Journal: Lancet Date: 1974-09-14 Impact factor: 79.321

6. Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia.

Authors: Y S Choi; W D Biggar; R A Good
Journal: Lancet Date: 1972-05-27 Impact factor: 79.321

7. Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 9-beta-D-arabinofuranosyladenine.

Authors: J J Furth; S S Cohen
Journal: Cancer Res Date: 1967-09 Impact factor: 12.701

8. Dual pathway of B lymphocyte differentiation in vitro.

Authors: B A Askonas; G E Roelants; K S Mayor-Withey; J L Welstead
Journal: Eur J Immunol Date: 1976-04 Impact factor: 5.532

9. The stimulation of immunoglobulin production in murine spleen cells by the pokeweed mitogens.

Authors: T Y Basham; M J Waxdal
Journal: J Immunol Date: 1975-02 Impact factor: 5.422

10. Immunological studies of human gamma-globulin. Relation of the precipitin lines of whole gamma-globulin to those of the fragments produced by papain.

Authors: G M EDELMAN; J F HEREMANS; M T HEREMANS; H G KUNKEL
Journal: J Exp Med Date: 1960-07-01 Impact factor: 14.307

5 in total

Differentiation of human peripheral blood B lymphocytes.

1. The effects of purified mitogenic proteins (Pa-1 and Pa-2) from pokeweed on human T and B lymphocytes in vitro.

2. Deoxyriboside control and synchronization of mitosis.

Review 3. Electron microscopic and functional aspects of human lymphocyte response to mitogens.

Review 4. Elicitation of selective T and B lymphocyte responses by cell surface binding ligands.

5. Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.

6. Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia.

7. Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 9-beta-D-arabinofuranosyladenine.

8. Dual pathway of B lymphocyte differentiation in vitro.

9. The stimulation of immunoglobulin production in murine spleen cells by the pokeweed mitogens.

10. Immunological studies of human gamma-globulin. Relation of the precipitin lines of whole gamma-globulin to those of the fragments produced by papain.

1. Kinetics of mitogen-induced proliferation and differentiation of human peripheral blood B lymphocytes.

2. In vitro immunoglobulin synthesis by human intestinal lamina propria lymphocytes.

3. Corticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes.

4. Human peripheral blood lymphocyte activation by protein A from Staphylococcus aureus.

5. TPA (12-O-tetradecanoyl-phorbol-13-acetate) activation and differentiation of human peripheral B lymphocytes.