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Literature DB >> 485853

Pharmacokinetics of halogenated ethylenes in rats.

J G Filser, H M Bolt.

Abstract

Entities: Chemical Species

Mesh：

Substances：

Year: 1979 PMID： 485853 DOI： 10.1007/bf00316492

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

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11 in total

1. Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.

Authors: H Kappus; H M Bolt; A Buchter; W Bolt
Journal: Toxicol Appl Pharmacol Date: 1976-09 Impact factor: 4.219

2. Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation.

Authors: G Bonse; T Urban; D Reichert; D Henschler
Journal: Biochem Pharmacol Date: 1975-10-01 Impact factor: 5.858

3. Disposition of (1,2-14C) vinyl chloride in the rat.

Authors: H M Bolt; H Kappus; A Buchter; W Bolt
Journal: Arch Toxicol Date: 1976-06-08 Impact factor: 5.153

4. Rat liver microsomal uptake and irreversible protein binding of [1,2-14C]vinyl bromide.

Authors: H M Bolt; J G Filser; R K Hinderer
Journal: Toxicol Appl Pharmacol Date: 1978-06 Impact factor: 4.219

5. Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites.

Authors: H M Bolt; A Buchter; L Wolowski; D L Gil; W Bolt
Journal: Int Arch Occup Environ Health Date: 1977-06-30 Impact factor: 3.015

Review 6. Pharmacokinetics of vinyl chloride.

Authors: H M Bolt
Journal: Gen Pharmacol Date: 1978

7. Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example--vinyl chloride.

Authors: P J Gehring; P G Watanabe; C N Park
Journal: Toxicol Appl Pharmacol Date: 1978-06 Impact factor: 4.219

8. Uptake and hepatotoxicity of 1,1-dichloroethylene by the isolated blood-perfused rat liver.

Authors: D Reichert; D Henschler
Journal: Int Arch Occup Environ Health Date: 1978-05-12 Impact factor: 3.015

9. Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration.

Authors: M J McKenna; J A Zempel; E O Madrid; W H Braun; P J Gehring
Journal: Toxicol Appl Pharmacol Date: 1978-09 Impact factor: 4.219

10. Pharmacokinetics of vinyl chloride in the rat.

Authors: H M Bolt; R J Laib; H Kappus; A Buchter
Journal: Toxicology Date: 1977-04 Impact factor: 4.221

34 in total

1. Use of linear free energy relationships in toxicology: prediction of partition coefficients of volatile lipophilic compounds.

Authors: G A Csanády; R J Laib
Journal: Arch Toxicol Date: 1990 Impact factor: 5.153

Review 2. The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

Authors: J G Filser
Journal: Arch Toxicol Date: 1992 Impact factor: 5.153

Pharmacokinetics of halogenated ethylenes in rats.

1. Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.

2. Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation.

3. Disposition of (1,2-14C) vinyl chloride in the rat.

4. Rat liver microsomal uptake and irreversible protein binding of [1,2-14C]vinyl bromide.

5. Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites.

Review 6. Pharmacokinetics of vinyl chloride.

7. Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example--vinyl chloride.

8. Uptake and hepatotoxicity of 1,1-dichloroethylene by the isolated blood-perfused rat liver.

9. Metabolism and pharmacokinetic profile of vinylidene chloride in rats following oral administration.

10. Pharmacokinetics of vinyl chloride in the rat.

1. Use of linear free energy relationships in toxicology: prediction of partition coefficients of volatile lipophilic compounds.

Review 2. The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.

3. Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats.

4. Inhaled ethylene oxide induces preneoplastic foci in rat liver.

5. Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats.

6. Kinetics and disposition in toxicology. Example: carcinogenic risk estimate for ethylene.

7. Formation of pre-neoplastic hepatocellular foci by vinyl bromide in newborn rats.

8. Metabolism and pharmacokinetics of vinyl acetate.

9. Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models.

10. Malignant tumors after chronic exposure to vinyl chloride.