Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.

Literature DB >> 4853617

Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.

Abstract

1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1974 PMID： 4853617 PMCID： PMC1776707 DOI： 10.1111/j.1476-5381.1974.tb09616.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

22 in total

1. The effect of phenobarbitone-induction on vitamin D metabolism.

Authors: J Silver; G Neale; D Davies; A Breckenridge; G R Thompson
Journal: Clin Sci Date: 1972-02 Impact factor: 6.124

2. Diphenylhydantoin and ion flux in lobster nerve.

Authors: J H Pincus
Journal: Arch Neurol Date: 1972-01

3. [Osteopathies in antiepileptic long-term therapy (preliminary report)].

Authors: R Kruse
Journal: Monatsschr Kinderheilkd Date: 1968-06

4. A sensitive in vitro method for studying the induction and inhibition of bone resorption.

Authors: J J Reynolds; J T Dingle
Journal: Calcif Tissue Res Date: 1970

5. Studies on the metabolism of phenytoin.

Authors: B N Jensen; V Grynderup
Journal: Epilepsia Date: 1966-09 Impact factor: 5.864

6. Disturbance of calcium metabolism by anticonvulsant drugs.

Authors: A Richens; D J Rowe
Journal: Br Med J Date: 1970-10-10

7. Influence of sodium on calcium transport by the rat small intestine.

Authors: D L Martin; H F DeLuca
Journal: Am J Physiol Date: 1969-06

8. The effect of ascorbic acid on the growth of chick bone rudiments in chemically defined medium.

Authors: J J Reynolds
Journal: Exp Cell Res Date: 1966-04 Impact factor: 3.905

9. Osteomalacia with long-term anticonvulsant therapy in epilepsy.

Authors: C E Dent; A Richens; D J Rowe; T C Stamp
Journal: Br Med J Date: 1970-10-10

10. Altered calcium metabolism in epileptic children on anticonvulsants.

Authors: J Hunter; J D Maxwell; D A Stewart; V Parsons; R Williams
Journal: Br Med J Date: 1971-10-23

7 in total

1. Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.

Authors: T J Hahn; C R Scharp; C A Richardson; L R Halstead; A J Kahn; S L Teitelbaum
Journal: J Clin Invest Date: 1978-08 Impact factor: 14.808

2. The effect of phenytoin on parathyroid extract and 25-hydroxycholecalciferol-induced bone resorption: adenosine 3, 5 cyclic monophosphate production.

Authors: M V Jenkins; M Harris; M R Wills
Journal: Calcif Tissue Res Date: 1974