Literature DB >> 22761220

Generalised stunting of roots in an epileptic child: is long-term phenytoin therapy the cause?

Garima Jindal1, Ramesh K Pandey, Dipanshu Kumar.   

Abstract

Long-term phenytoin therapy is known to cause disturbance in calcium and bone homeostasis. Dental tissues being calcified tissues can also be affected by this derangement of mineral metabolism, especially during developmental phases. This report describes a case of an epileptic child who presented with short roots, enlarged pulp chambers, blunt apices and delayed eruption of permanent dentition, which might be attributed to long-term phenytoin therapy. The purpose of this case report is to increase awareness among the clinicians about its possible dental implications and emphasise upon the need of regular dental check-ups in epileptic children.

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Year:  2012        PMID: 22761220      PMCID: PMC4543127          DOI: 10.1136/bcr-03-2012-6042

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  13 in total

1.  Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.

Authors:  T J Hahn; C R Scharp; C A Richardson; L R Halstead; A J Kahn; S L Teitelbaum
Journal:  J Clin Invest       Date:  1978-08       Impact factor: 14.808

2.  Prevalence of short-root anomaly in healthy young adults.

Authors:  Satu Apajalahti; Päivi Hölttä; Lauri Turtola; Sinikka Pirinen
Journal:  Acta Odontol Scand       Date:  2002-01       Impact factor: 2.331

3.  Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenyl hydantoin in tissue culture.

Authors:  M Harris; P Goldhaber
Journal:  Arch Oral Biol       Date:  1974-11       Impact factor: 2.633

4.  Epilepsy and the oral manifestations of phenytoin therapy.

Authors:  T M Hassell
Journal:  Monogr Oral Sci       Date:  1981

5.  Prevalence and pattern of epilepsy in India.

Authors:  R Sridharan; B N Murthy
Journal:  Epilepsia       Date:  1999-05       Impact factor: 5.864

Review 6.  Bone loss associated with use of antiepileptic drugs.

Authors:  Karl O Nakken; Erik Taubøll
Journal:  Expert Opin Drug Saf       Date:  2010-07       Impact factor: 4.250

7.  Cessation of dental development in a child with idiopathic hypoparathyroidism: a 5-year follow-up.

Authors:  Alice Kelly; Luciana Pomarico; Ivete Pomarico Ribeiro de Souza
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod       Date:  2009-02-08

8.  Pseudohypoparathyroidism: case report.

Authors:  M D Brown; G Aaron
Journal:  Pediatr Dent       Date:  1991 Mar-Apr       Impact factor: 1.874

9.  Tooth root resorption induced in rats by diphenylhydantoin and parathyroidectomy.

Authors:  P B Robinson; W Harvey
Journal:  Br J Exp Pathol       Date:  1989-02

10.  Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.

Authors:  M Harris; M V Jenkins; M R Wills
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

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  1 in total

1.  Stunted root development: A rare dental complication of Stevens-Johnson syndrome.

Authors:  Aditi Sangwan; Hans-Raj Saini; Pankaj Sangwan; Parveen Dahiya
Journal:  J Clin Exp Dent       Date:  2016-10-01
  1 in total

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