Literature DB >> 5312062

Osteomalacia with long-term anticonvulsant therapy in epilepsy.

C E Dent, A Richens, D J Rowe, T C Stamp.   

Abstract

The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy. It is suggested that drug-mediated enzyme induction may be the mechanism responsible by causing a greatly increased inactivation of vitamin D in these patients.

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Year:  1970        PMID： 5312062      PMCID： PMC1819593          DOI： 10.1136/bmj.4.5727.69

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  8 in total

Review 1.  Current concepts. Vitamin D.

Authors:  H F DeLuca
Journal:  N Engl J Med       Date:  1969-11-13       Impact factor: 91.245

2.  The role of the liver in the metabolism of vitamin D.

Authors:  G Ponchon; H F DeLuca
Journal:  J Clin Invest       Date:  1969-07       Impact factor: 14.808

3.  25-hydroxycholecalciferol. The probable metabolically active form of vitamin D3: its identification and subcellular site of action.

Authors:  H F DeLuca
Journal:  Arch Intern Med       Date:  1969-10

4.  Absorption and metabolism of vitamin D3 in man.

Authors:  L V Avioli
Journal:  Am J Clin Nutr       Date:  1969-04       Impact factor: 7.045

5.  Theoretical renal phosphorus threshold in investigation and treatment of osteomalacia.

Authors:  C E Dent; T C Stamp
Journal:  Lancet       Date:  1970-04-25       Impact factor: 79.321

6.  Mechanism of action and metabolic fate of vitamin D.

Authors:  H F DeLuca
Journal:  Vitam Horm       Date:  1967       Impact factor: 3.421

7.  Disturbance of calcium metabolism by anticonvulsant drugs.

Authors:  A Richens; D J Rowe
Journal:  Br Med J       Date:  1970-10-10

8.  Reversible absorptive defects in anticonvulsant megaloblastic anaemia.

Authors:  E H Reynolds; J F Hallpike; B M Phillips; D M Matthews
Journal:  J Clin Pathol       Date:  1965-09       Impact factor: 3.411
  8 in total
  89 in total

1.  Bone morphology in epileptics.

Authors:  O Johnell; B E Nilsson; A Wallöe; P E Wiklund
Journal:  Calcif Tissue Int       Date:  1979-10-31       Impact factor: 4.333

2.  Bone mineral content in epileptics.

Authors:  L Lidgren; B E Nilsson; A Wallöe
Journal:  Calcif Tissue Int       Date:  1979-10-31       Impact factor: 4.333

3.  Effects of anticonvulsants and inactivity on bone disease in epileptics.

Authors:  L E Murchison; P D Bewsher; M Chesters; J Gilbert; G Catto; E Law; E McKay; H S Ross
Journal:  Postgrad Med J       Date:  1975-01       Impact factor: 2.401

4.  The Association Between Antiepileptic Drugs and Bone Disease.

Authors:  Alison M. Pack
Journal:  Epilepsy Curr       Date:  2003-05       Impact factor: 7.500

5.  The "top 50": a perspective on the BMJ drawn from the Science Citation Index.

Authors:  B Dixon
Journal:  BMJ       Date:  1990-10-03

6.  The clinical consequences of chronic hepatic enzyme induction by anticonvulsant drugs.

Authors:  A Richens
Journal:  Br J Clin Pharmacol       Date:  1974-06       Impact factor: 4.335

Review 7.  Drug-induced arthritis and arthralgia.

Authors:  F D Hart
Journal:  Drugs       Date:  1984-10       Impact factor: 9.546

8.  Plasma levels and therapeutic effect of 25-hydroxycholecalciferol in epileptic patients taking anticonvulsant drugs.

Authors:  T C Stamp; J M Round; D J Rowe; J G Haddad
Journal:  Br Med J       Date:  1972-10-07

9.  Hypocalcaemic cardiac failure.

Authors:  D P Brenton; J Gonzales; A B Pollard
Journal:  Postgrad Med J       Date:  1978-09       Impact factor: 2.401

10.  [The frequency of adult anticonvulsant osteomalacia in relation to duration of therapy and dosage of anticonvulsants (author's transl)].

Authors:  U Mehregan; K H Krause; P Prager
Journal:  Arch Psychiatr Nervenkr (1970)       Date:  1979-04-12
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