Literature DB >> 4840443

Preparation of succinyl neocarzinostatin.

H Maeda.   

Abstract

All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis-N-succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.

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Year:  1974        PMID： 4840443      PMCID： PMC428972          DOI： 10.1128/AAC.5.3.354

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  NEOCARZINOSTATIN, AN ANTITUMOR ANTIBIOTIC OF HIGH MOLECULAR WEIGHT. ISOLATION, PHYSIOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES.

Authors:  N ISHIDA; K MIYAZAKI; K KUMAGAI; M RIKIMARU
Journal:  J Antibiot (Tokyo)       Date:  1965-03       Impact factor: 2.649

2.  Primary structure of neocarzinostatin, an antitumor protein.

Authors:  J Meienhofer; H Maeda; C B Glaser; J Czombos; K Kuromizu
Journal:  Science       Date:  1972-11-24       Impact factor: 47.728

3.  Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.

Authors:  Y Hinuma; J T Grace
Journal:  Proc Soc Exp Biol Med       Date:  1967-01

4.  Conformation of antibiotic protein, neocarzinostatin, studied by plane polarized infrared spectroscopy, circular dichroism and optical rotatory dispersion.

Authors:  H Maeda; H Shiraishi; S Onodera; N Ishida
Journal:  Int J Pept Protein Res       Date:  1973

5.  Succinylation of pepsinogen.

Authors:  A D Gounaris; G E Perlmann
Journal:  J Biol Chem       Date:  1967-06-10       Impact factor: 5.157

6.  Separation of dansyl-amino acids by polyamide layer chromatography.

Authors:  K R Woods; K T Wang
Journal:  Biochim Biophys Acta       Date:  1967-02-21

7.  Characterization of neocarzinostatin.

Authors:  H Maeda; K Kumagai; N Ishida
Journal:  J Antibiot (Tokyo)       Date:  1966-11       Impact factor: 2.649
  7 in total
  1 in total

1.  Mechanism of accumulation of the antitumor protein antibiotic neocarzinostatin in bladder tissue: intravenous administration, urinary excretion, and absorption into bladder tissue.

Authors:  H Maeda; S Sakamoto; J Ogata
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191
  1 in total

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