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Literature DB >> 4563817

Primary structure of neocarzinostatin, an antitumor protein.

J Meienhofer, H Maeda, C B Glaser, J Czombos, K Kuromizu.

Abstract

The antitumor protein neocarzinostatin is an acidic single-chain molecule, cross-linked by two disulfide bridges, and consists of 109 amino acid residues. Complete disulfide bond reduction and S-carboxymethylation was achieved in liquid ammonia. Sequence determination of five tryptic fragments led to the proposed primary structure.

Entities: Chemical

Mesh：

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Year: 1972 PMID： 4563817 DOI： 10.1126/science.178.4063.875

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

12 in total

1. Nucleotide specificity in DNA scission by neocarzinostatin.

Authors: T Hatayama; I H Goldberg; M Takeshita; A P Grollman
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

2. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

Authors: A D D'Andrea; W A Haseltine
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

3. Purification and characterization of a bacteriocin from Bacteroides fragilis.

Authors: T J Hayes; K R Cundy; P B Fernandes; J K Hoober
Journal: J Bacteriol Date: 1983-09 Impact factor: 3.490

4. Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells.

Authors: Y J Xu; D D Li; Y S Zhen
Journal: Cancer Chemother Pharmacol Date: 1990 Impact factor: 3.333

10. A tentative model of the intercalative binding of the neocarzinostatin chromophore to double-stranded tetranucleotides.

Authors: K X Chen; N Gresh; B Pullman
Journal: Nucleic Acids Res Date: 1987-03-11 Impact factor: 16.971

Primary structure of neocarzinostatin, an antitumor protein.

1. Nucleotide specificity in DNA scission by neocarzinostatin.

2. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

3. Purification and characterization of a bacteriocin from Bacteroides fragilis.

4. Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human hepatoma BEL-7402 cells.

5. Identification of thymidine-5'-aldehyde at DNA strand breaks induced by neocarzinostatin chromophore.

6. Characterization of intracellular DNA strand breaks induced by neocarzinostatin in Escherichia coli cells.

7. Activation and inactivation of neocarzinostatin-induced cleavage of DNA.

8. Preparation of succinyl neocarzinostatin.

9. Roles of chromophore and apo-protein in neocarzinostatin action.

10. A tentative model of the intercalative binding of the neocarzinostatin chromophore to double-stranded tetranucleotides.