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Literature DB >> 909781

Photoproducts from DNA pyrimidine bases and polycyclic aromatic hydrocarbons.

G M Blackburn, R G Fenwick, G Lockwood, G M Williams.

Abstract

The major photoproduct formed between benzo[a]pyrene and thymine is identified as 1-(benzo[a]pyren-6-yl)-thymine by means of spectroscopic analysis and isotopic syntheses. Irradiation of 1-methylcytosine hydrochloride and anthracene gives two isolable photoproducts of which one is assigned the structure 5-(anthracen-9-yl)-1-methylcytosine.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 909781 PMCID： PMC342581 DOI： 10.1093/nar/4.7.2487

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

13 in total

1. Tritium incorporation at specific positions in benzo(a)pyrene.

Authors: D Warshawsky; M Calvin
Journal: Biochem Biophys Res Commun Date: 1975-04-07 Impact factor: 3.575

2. Photocyclo addition of acetone to uracil and cytosine.

Authors: A J Varghese
Journal: Photochem Photobiol Date: 1975-03 Impact factor: 3.421

3. INTERACTION OF NUCLEIC ACIDS, II. CHEMICAL LINKAGE OF THE CARCINOGEN 3,4-BENZPYRENE TO DNA INDUCED BY PHOTORADIATION.

Authors: P O TSO; P LU
Journal: Proc Natl Acad Sci U S A Date: 1964-02 Impact factor: 11.205

4. [Experimental investigations of photogenous cancer; cancerogenic photosensitization].

Authors: W HELLER
Journal: Strahlentherapie Date: 1950

5. Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct.

Authors: A M Jeffrey; K W Jennette; S H Blobstein; I B Weinstein; F A Beland; R G Harvey; H Kasal; I Miura; K Nakanishi
Journal: J Am Chem Soc Date: 1976-09-01 Impact factor: 15.419

6. Chemical linkage of polycyclic hydrocarbons to deoxyribonucleic acids and polynucleotides in aqueous solution and in a buffer-ethanol solvent system.

Authors: H D Hoffmann; S A Lesko; P O Ts'o
Journal: Biochemistry Date: 1970-06-23 Impact factor: 3.162

7. Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography.

Authors: J K Selkirk; R G Croy; H V Gelboin
Journal: Science Date: 1974-04-12 Impact factor: 47.728

8. Photochemical binding of anthracene and other aromatic hydrocarbons to deoxyribonucleic acid with attendant loss of tritium.

Authors: G M Blackburn; J Buckingham; R G Fenwick; P Taussig; M H Thompson
Journal: J Chem Soc Perkin 1 Date: 1973

Photoproducts from DNA pyrimidine bases and polycyclic aromatic hydrocarbons.

1. Tritium incorporation at specific positions in benzo(a)pyrene.

2. Photocyclo addition of acetone to uracil and cytosine.

3. INTERACTION OF NUCLEIC ACIDS, II. CHEMICAL LINKAGE OF THE CARCINOGEN 3,4-BENZPYRENE TO DNA INDUCED BY PHOTORADIATION.

4. [Experimental investigations of photogenous cancer; cancerogenic photosensitization].

5. Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct.

6. Chemical linkage of polycyclic hydrocarbons to deoxyribonucleic acids and polynucleotides in aqueous solution and in a buffer-ethanol solvent system.

7. Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography.

8. Photochemical binding of anthracene and other aromatic hydrocarbons to deoxyribonucleic acid with attendant loss of tritium.

9. Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

Review 10. Carcinogenic mechanisms: a critical review and a suggestion that oncogenesis may be adaptive ontogenesis.

1. UVA light-induced DNA cleavage by selected polycyclic aromatic hydrocarbons.

Review 2. Environmental carcinogenic polycyclic aromatic hydrocarbons: photochemistry and phototoxicity.