Literature DB >> 4799669

Synthesis of cephalosporin C from sulfate by mutants of Cephalosporium acremonium.

H F Niss, C H Nash.   

Abstract

The innate ability of Cephalosporium acremonium to use methionine preferentially over sulfate for synthesis of cephalosporin C can be influenced through mutation. Mutants of C. acremonium with altered capacity to utilize sulfate for synthesis of antibiotic were isolated and partially characterized with respect to the uptake of sulfate and the regulation of arylsulfatase.

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Year:  1973        PMID： 4799669      PMCID： PMC444579          DOI： 10.1128/AAC.4.4.474

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  INTERMEDIATES IN INORGANIC SULFATE UTILIZATION BY PENICILLIUM CHRYSOGENUM.

Authors:  I H SEGEL; M J JOHNSON
Journal:  Arch Biochem Biophys       Date:  1963-11       Impact factor: 4.013

2.  Further evidence on the identity of cystathionase and cysteine desulfhydrase.

Authors:  B MONDOVI; A SCIOSCIA-SANTORO
Journal:  Arch Biochem Biophys       Date:  1963-05       Impact factor: 4.013

3.  Biosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.

Authors:  J L Ott; C W Godzeski; D Pavey; J D Farran; D R Horton
Journal:  Appl Microbiol       Date:  1962-11

4.  Positive control by the cys-3 locus in regulation of sulfur metabolism in Neurospora.

Authors:  G A Marzluf; R L Metzenberg
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

5.  A century of compounds and their effect on fungi.

Authors:  P A Lemke
Journal:  Mycopathol Mycol Appl       Date:  1969-07-28

6.  Sulfatase regulation and antibiotic synthesis in Cephalosporium acremonium.

Authors:  D W Dennen; D D Carver
Journal:  Can J Microbiol       Date:  1969-02       Impact factor: 2.419

7.  The inorganic sulfate transport system of Penicillium chrysogenum.

Authors:  L A Yamamoto; I H Segel
Journal:  Arch Biochem Biophys       Date:  1966-06       Impact factor: 4.013

8.  Role of methionine in cephalosporin synthesis.

Authors:  P G Caltrider; H F Niss
Journal:  Appl Microbiol       Date:  1966-09

9.  Genetic and metabolic controls for sulfate metabolism in Neurospora crassa: isolation and study of chromate-resistant and sulfate transport-negative mutants.

Authors:  G A Marzluf
Journal:  J Bacteriol       Date:  1970-06       Impact factor: 3.490

10.  Biosynthesis of cephalosporin C.

Authors:  A L DEMAIN; J F NEWKIRK
Journal:  Appl Microbiol       Date:  1962-07
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