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Literature DB >> 13885285

Biosynthesis of cephalosporin C.

Abstract

The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cysteine showed considerable methionine-replacing activity. Lysine and alpha-aminoadipic acid were inactive.

Entities: Chemical

Keywords: ANTIBIOTICS/metabolism

Mesh：

Substances：

Year: 1962 PMID： 13885285 PMCID： PMC1057867 DOI： 10.1128/am.10.4.321-325.1962

Source DB: PubMed Journal: Appl Microbiol ISSN： 0003-6919

9 in total

1. Cephalosporin C, a new antibiotic containing sulphur and D-alpha-aminoadipic acid.

Authors: G G NEWTON; E P ABRAHAM
Journal: Nature Date: 1955-03-26 Impact factor: 49.962

2. Metabolic relationship between cystathionine and methionine in Neurospora.

Authors: J L WIEBERS; H R GARNER
Journal: J Bacteriol Date: 1960-07 Impact factor: 3.490

3. New penicillins, cephalosporin C, and penicillinase.

Authors: E P ABRAHAM; G G NEWTON
Journal: Endeavour Date: 1961-04 Impact factor: 0.444

4. Further studies on the repression of methionine synthesis in Escherichia coli.

Authors: R J ROWBURY; D D WOODS
Journal: J Gen Microbiol Date: 1961-01

5. The mechanism of penicillin biosynthesis.

Authors: A L DEMAIN
Journal: Adv Appl Microbiol Date: 1959 Impact factor: 5.086

6. D-methionine and the biosynthesis of cephalosporin N.

Authors: F KAVANAGH; D TUNIN; G WILD
Journal: Arch Biochem Biophys Date: 1958-10 Impact factor: 4.013

7. S-methyl-L-cysteine as a naturally occurring metabolite in Neurospora crassa.

Authors: J L LIVERMAN; J B RAGLAND
Journal: Arch Biochem Biophys Date: 1956-12 Impact factor: 4.013

8. Growth response of Streptococcus faecalis to the stereoisomers of methionine and some derivatives.

Authors: G D SHOCKMAN; G TOENNIES
Journal: Arch Biochem Biophys Date: 1954-05 Impact factor: 4.013

9. Reduction of methionine sulfoxides by Escherichia coli.

Authors: T L SOURKES; Y TRANO
Journal: Arch Biochem Biophys Date: 1953-02 Impact factor: 4.013

9 in total

12 in total

9. Isolation of regulatory mutants of the aspartic and pyruvic acid families and their effect on antibiotic production in Streptomyces lipmanii.

Authors: O W Godfrey
Journal: Antimicrob Agents Chemother Date: 1973-08 Impact factor: 5.191

10. Synthesis of cephalosporin C from sulfate by mutants of Cephalosporium acremonium.

Authors: H F Niss; C H Nash
Journal: Antimicrob Agents Chemother Date: 1973-10 Impact factor: 5.191

Biosynthesis of cephalosporin C.

1. Cephalosporin C, a new antibiotic containing sulphur and D-alpha-aminoadipic acid.

2. Metabolic relationship between cystathionine and methionine in Neurospora.

3. New penicillins, cephalosporin C, and penicillinase.

4. Further studies on the repression of methionine synthesis in Escherichia coli.

5. The mechanism of penicillin biosynthesis.

6. D-methionine and the biosynthesis of cephalosporin N.

7. S-methyl-L-cysteine as a naturally occurring metabolite in Neurospora crassa.

8. Growth response of Streptococcus faecalis to the stereoisomers of methionine and some derivatives.

9. Reduction of methionine sulfoxides by Escherichia coli.

1. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media.

2. Effect of Methionine and Sulfate on the Metabolism of Cephalosporium acremonium.

3. The isolation and characterization of auzotrophs of the aspartic acid family from Streptomyces lipmanii.

4. A chemically defined medium for cephalosporin C production by Paecilomyces persicinus.

5. Role of methionine in cephalosporin synthesis.

6. Formation of desacetylcephalosporin C in cephalosporin C fermentation.

7. Production of cephalosporin C by Paecilomyces persicinus P-10.

8. Nonbiological conversion of cephalosporin C to a new antibiotic by sodium thiosulfate.

9. Isolation of regulatory mutants of the aspartic and pyruvic acid families and their effect on antibiotic production in Streptomyces lipmanii.

10. Synthesis of cephalosporin C from sulfate by mutants of Cephalosporium acremonium.