Literature DB >> 477859

Inhibition of alpha-chymotrypsin by 2-halogeno-ethanols; comparisons with 2-methyl-ethanols and urea.

S Ebina, T Kobayashi, Y Nagai.   

Abstract

2-Halogeno- and 2-methyl-ethanols inhibit alpha-chymotrypsin in the order of their substituted groups: [1] tri- greater than di- greater than mono-, [2] Br- greater than Cl- greater than CH3- greater than F-. The inhibition by the halogeno-ethanols is mediated differently from that by the methyl-ethanols, ethanol, and urea.

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Year:  1979        PMID： 477859     DOI： 10.1007/bf01949911

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  The charge-relay system of serine proteinases: proton magnetic resonance titration studies of the four histidines of porcine trypsin.

Authors:  J L Markley; M A Porubcan
Journal:  J Mol Biol       Date:  1976-04-15       Impact factor: 5.469

2.  THE SOLUBILITY OF AMINO ACIDS AND RELATED COMPOUNDS IN AQUEOUS UREA SOLUTIONS.

Authors:  Y NOZAKI; C TANFORD
Journal:  J Biol Chem       Date:  1963-12       Impact factor: 5.157

3.  A new spectrophotometric method for the determination of chymotrypsin activity.

Authors:  H F BUNDY
Journal:  Anal Biochem       Date:  1962-05       Impact factor: 3.365

4.  Some factors in the interpretation of protein denaturation.

Authors:  W KAUZMANN
Journal:  Adv Protein Chem       Date:  1959

5.  Three-dimensional structure of tosyl-alpha-chymotrypsin.

Authors:  B W Matthews; P B Sigler; R Henderson; D M Blow
Journal:  Nature       Date:  1967-05-13       Impact factor: 49.962

6.  Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.

Authors:  J J Birktoft; D M Blow
Journal:  J Mol Biol       Date:  1972-07-21       Impact factor: 5.469

7.  On the structural stability and solvent denaturation of proteins. II. Denaturation by the ureas.

Authors:  T T Herskovits; H Jaillet; B Gadegbeku
Journal:  J Biol Chem       Date:  1970-09-10       Impact factor: 5.157

8.  Role of a buried acid group in the mechanism of action of chymotrypsin.

Authors:  D M Blow; J J Birktoft; B S Hartley
Journal:  Nature       Date:  1969-01-25       Impact factor: 49.962
  8 in total
  2 in total

1.  2-Halogeno-ethanols as an uncoupler of phosphorylation in rat liver mitochondria.

Authors:  S Ebina; Y Nagai
Journal:  Experientia       Date:  1980-05-15

2.  Active site structural change of alpha-chymotrypsin due to 2-halogeno-ethanols; comparison with ethanol, I-propanol, and urea.

Authors:  S Ebina; Y Nagai
Journal:  Experientia       Date:  1980-05-15
  2 in total

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