Literature DB >> 1211306

The mechanism whereby growth hormone-release inhibiting hormone (somatostatin) inhibits food stimulated gastric acid secretion in the cat.

M Albinus, E L Blair, E R Grund, J D Reed, D J Sanders, A Gomez-Pan, A V Schally, G M Besser.   

Abstract

Growth hormone-release inhibiting hormone (somatostatin) inhibits the gastric acid response to food in concious cats. We have confirmed that this tetradecapeptide blocks the food stimulated gastrin release. However, the inhibition of gastrin release is delayed relative to that of acid secretion, &howing that the inhibition of food stimulated acid secretion is by primary effect on the acid secretory mechanism. No evidence was found of potentiation of either the gastric acid output or serum concentration of gastric in response to food.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1211306     DOI： 10.1007/bf02205235

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  13 in total

1.  Some actions of growth hormone release inhibiting factor.

Authors:  A P Hansen; H Orskov; K Seyer-Hansen; K Lundbaek
Journal:  Br Med J       Date:  1973-09-08

2.  Solid phase synthesis of growth hormone-release inhibiting factor.

Authors:  D H Coy; E J Coy; A Arimura; A V Schally
Journal:  Biochem Biophys Res Commun       Date:  1973-10-15       Impact factor: 3.575

3.  Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients.

Authors:  C H Mortimer; W M Tunbridge; D Carr; L Yeomans; T Lind; D H Coy; S R Bloom; A Kastin; C N Mallinson; G M Besser; A V Schally; R Hall
Journal:  Lancet       Date:  1974-04-20       Impact factor: 79.321

4.  Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.

Authors:  S R Bloom; C H Mortimer; M O Thorner; G M Besser; R Hall; A Gomez-Pan; V M Roy; R C Russell; D H Coy; A J Kastin; A V Schally
Journal:  Lancet       Date:  1974-11-09       Impact factor: 79.321

5.  Action of growth-hormone-release inhibitory hormone in healthy men and in acromegaly.

Authors:  R Hall; G M Besser; A V Schally; D H Coy; D Evered; D J Goldie; A J Kastin; A S McNeilly; C H Mortimer; C Phenekos; W M Tunbridge; D Weightman
Journal:  Lancet       Date:  1973-09-15       Impact factor: 79.321

6.  Inhibition of insulin secretion by somatostatin.

Authors:  K G Alberti; N J Christensen; S E Christensen; A P Hansen; J Iversen; K Lundbaek; K Seyer-Hansen; H Orskov
Journal:  Lancet       Date:  1973-12-08       Impact factor: 79.321

7.  Immunochemical studies with synthetic human gastrin.

Authors:  J E McGuigan
Journal:  Gastroenterology       Date:  1968-06       Impact factor: 22.682

8.  Inhibition of growth hormone release in humans by somatostatin.

Authors:  T M Siler; G VandenBerg; S S Yen; P Brazeau; W Vale; R Guillemin
Journal:  J Clin Endocrinol Metab       Date:  1973-10       Impact factor: 5.958

9.  Preparation of 125 I-labelled synthetic human gastrin I for radioimmunoanalysis.

Authors:  F Stadil; J F Rehfeld
Journal:  Scand J Clin Lab Invest       Date:  1972-12       Impact factor: 1.713

10.  Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs.

Authors:  A A Barros D'Sa; S R Bloom; J H Baron
Journal:  Lancet       Date:  1975-04-19       Impact factor: 79.321
View more
  6 in total

1.  Comparison of the inhibition of histamine- and pentagastrin-stimulated gastric acid secretion by somatostatin in the cat.

Authors:  M Albinus; J D Reed; A Gomez-Pan; A V Schally; D H Coy
Journal:  Agents Actions       Date:  1977-12

2.  Topography of somatostatin cells in the stomach of the rat: possible functional significance.

Authors:  J Alumets; M Ekelund; H A El Munshid; R Håkanson; I Lorén; F Sundler
Journal:  Cell Tissue Res       Date:  1979-11       Impact factor: 5.249

3.  Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat.

Authors:  M Moriga; K Kojima; M Aono; H Uchino; H Yajima
Journal:  Gastroenterol Jpn       Date:  1978

4.  Structure-activity relationships of eighteen somatostatin analogues on gastric secretion.

Authors:  M P Brown; D H Coy; A Gomez-Pan; B H Hirst; M Hunter; C Meyers; J D Reed; A V Schally; B Shaw
Journal:  J Physiol       Date:  1978-04       Impact factor: 5.182

5.  Effect of suppression of endocrine or exocrine pancreatic function in hemorrhagic shock.

Authors:  M J Galvin; A M Lefer
Journal:  Experientia       Date:  1979-01-15

6.  Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Authors:  M Albinus; E L Blair; R M Case; D H Coy; A Gomez-Pan; B H Hirst; J D Reed; A V Schally; B Shaw; P A Smith; J R Smy
Journal:  J Physiol       Date:  1977-07       Impact factor: 5.182
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.