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Literature DB >> 4718964

Bactericidal activity of metronidazole against Bacteroides fragilis.

Abstract

Metronidazole was found to be active against Bacteroides fragilis strains isolated from human lesions. The minimal inhibitory concentrations (MIC) were from 0.16 to 2.5 mug/ml and the minimal bactericidal concentrations (MBC) were from 0.16 to 2.5 mug/ml; usually the MIC and MBC figures were equivalent. These levels are easily attainable in the serum following normal therapeutic doses. The drug is not toxic and side effects are rare and it would therefore seem highly suitable for treating Bacteroides infections and also may be considered prophylactically in certain situations that are described.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1973 PMID： 4718964 PMCID： PMC477766 DOI： 10.1136/jcp.26.6.393

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

19 in total

1. Combined agar diffusion and replica plating techniques in the study of antibacterial substances.

Authors: S D ELEK; G R HILSON
Journal: J Clin Pathol Date: 1954-02 Impact factor: 3.411

2. Metronidazole in amoebic dysentery and amoebic liver abscess.

Authors: S J Powell; I MacLeod; A J Wilmot; R Elsdon-Dew
Journal: Lancet Date: 1966-12-17 Impact factor: 79.321

3. Induction of in-vivo resistance of trichomonas vaginalis to nitrimidazine.

Authors: F Benazet; L Guillaume
Journal: Lancet Date: 1971-10-30 Impact factor: 79.321

4. Activity of metronidazole against experimental tetanus and gas gangrene.

Authors: W A Freeman; J A McFadzean; J P Whelan
Journal: J Appl Bacteriol Date: 1968-12

Review 5. Wound infection: etiology, prevention, and management, including selection of antibiotics.

Authors: J C Todd
Journal: Surg Clin North Am Date: 1968-08 Impact factor: 2.741

6. Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole.

Authors: J A McFadzean; I M Pugh; S L Squires; J P Whelan
Journal: Br J Vener Dis Date: 1969-06

7. Bacteroides pneumonias. Characteristics of cases with empyema.

Authors: J R Tillotson; A M Lerner
Journal: Ann Intern Med Date: 1968-02 Impact factor: 25.391

8. [The spectrum of antibacterial activity of metronidazole].

Authors: M Füzi; Z Csukás
Journal: Zentralbl Bakteriol Orig Date: 1970

9. The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro.

Authors: H R Ingham; J B Selkon; A A Codd; J H Hale
Journal: J Clin Pathol Date: 1970-04 Impact factor: 3.411

10. Trichomoniasis in a closed community: efficacy of metronidazole.

Authors: E E Keighley
Journal: Br Med J Date: 1971-01-23

25 in total

1. Letter: Metronidazole in treatment of empyema.

Authors: B J Smith; J Wellingham
Journal: Br Med J Date: 1976-05-01

2. A comparison of the in vitro activity of metronidazole, tinidazole, and nimorazole against Gram-negative anaerobic bacilli.

Authors: A V Reynolds; J M Hamilton-Miller; W Brumfitt
Journal: J Clin Pathol Date: 1975-10 Impact factor: 3.411

10. Synergism between penicillin, clindamycin, or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups.

Authors: I Brook; J C Coolbaugh; R I Walker; E Weiss
Journal: Antimicrob Agents Chemother Date: 1984-01 Impact factor: 5.191

Bactericidal activity of metronidazole against Bacteroides fragilis.

1. Combined agar diffusion and replica plating techniques in the study of antibacterial substances.

2. Metronidazole in amoebic dysentery and amoebic liver abscess.

3. Induction of in-vivo resistance of trichomonas vaginalis to nitrimidazine.

4. Activity of metronidazole against experimental tetanus and gas gangrene.

Review 5. Wound infection: etiology, prevention, and management, including selection of antibiotics.

6. Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole.

7. Bacteroides pneumonias. Characteristics of cases with empyema.

8. [The spectrum of antibacterial activity of metronidazole].

9. The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro.

10. Trichomoniasis in a closed community: efficacy of metronidazole.

1. Letter: Metronidazole in treatment of empyema.

2. A comparison of the in vitro activity of metronidazole, tinidazole, and nimorazole against Gram-negative anaerobic bacilli.

3. In vitro effect of metronidazole and tinidazole on anaerobic bacteria.

4. Pharmacokinetics of metronidazole as determined by bioassay.

5. Access of metronidazole into the chronically inflamed middle ear with reference to anaerobic bacterial infections.

Review 6. Bacterial synergy in pelvic inflammatory disease.

7. Treatment of anaerobic infections with metronidazole.

8. Antimicrobial susceptibilities of anaerobic bacteria: recent clinical isolates.

9. Methods for testing antibiotic sensitivity of anaerobic bacteria.

10. Synergism between penicillin, clindamycin, or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups.