Literature DB >> 4718113

6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate.

R E Heikkila, G Cohen.   

Abstract

Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations demonstrate the formation of the superoxide radical during the autoxidation process. This finding may be relevant to the mechanism of adrenergic nerve terminal degeneration caused by 6-hydroxydopamine.

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Year:  1973        PMID： 4718113     DOI： 10.1126/science.181.4098.456

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  36 in total

1.  In vitro inhibition of brain mitochondrial monoamine oxidase by 6-hydroxydopamine.

Authors:  M B Youdim
Journal:  Br J Pharmacol       Date:  1975-07       Impact factor: 8.739

2.  Selective neurotoxins, chemical tools to probe the mind: the first thirty years and beyond.

Authors:  R M Kostrzewa
Journal:  Neurotox Res       Date:  1999-09       Impact factor: 3.911

3.  Effects of superoxide radicals on transport (Na + K) adenosine triphosphatase and protection by superoxide dismutase.

Authors:  T D Hexum; R Fried
Journal:  Neurochem Res       Date:  1979-02       Impact factor: 3.996

4.  Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease.

Authors:  Shuei Sugama; Kazunari Sekiyama; Tohru Kodama; Yoshiki Takamatsu; Takato Takenouchi; Makoto Hashimoto; Conti Bruno; Yoshihiko Kakinuma
Journal:  Brain Behav Immun       Date:  2015-08-17       Impact factor: 7.217

Review 5.  Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease.

Authors:  Derek A Drechsel; Manisha Patel
Journal:  Free Radic Biol Med       Date:  2008-03-04       Impact factor: 7.376

6.  Antioxidant enzymatic systems in neuronal and glial cell-enriched fractions of rat brain during aging.

Authors:  E Geremia; D Baratta; S Zafarana; R Giordano; M R Pinizzotto; M G La Rosa; A Garozzo
Journal:  Neurochem Res       Date:  1990-07       Impact factor: 3.996

7.  One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity.

Authors:  Monica Villa; Patricia Muñoz; Ulises Ahumada-Castro; Irmgard Paris; Ana Jiménez; Isabel Martínez; Francisca Sevilla; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2013-02-06       Impact factor: 3.911

8.  Ethylene formation in sugar beet leaves: evidence for the involvement of 3-hydroxytyramine and phenoloxidase after wounding.

Authors:  E F Elstner; J R Konze; B R Selman; C Stoffer
Journal:  Plant Physiol       Date:  1976-08       Impact factor: 8.340

Review 9.  Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.

Authors:  Masato Asanuma; Ikuko Miyazaki; Norio Ogawa
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

Review 10.  Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.

Authors:  Ruben K Dagda; Charleen T Chu
Journal:  J Bioenerg Biomembr       Date:  2009-12       Impact factor: 2.945
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