| Literature DB >> 221849 |
Abstract
Membrane (Na +K)ATPase isolated from rat brain was preincubated in a medium in which superoxide radicals were generated enzymatically. Exposure to superoxide radicals caused an irreversible inactivation, which could be prevented by further addition of superoxide dismutase. (Na + K)ATPase was also protected by addition of allopurinol, a xanthine oxidase inhibitor, during preincubation. The K-activated nitrophenylphosphatase associated with (Na + K)ATPase was also found to be inactivated by preincubation with superoxide radicals, which could be prevented by superoxide dismutase.Entities:
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Year: 1979 PMID: 221849 DOI: 10.1007/bf00963833
Source DB: PubMed Journal: Neurochem Res ISSN: 0364-3190 Impact factor: 3.996