Literature DB >> 1164597

In vitro inhibition of brain mitochondrial monoamine oxidase by 6-hydroxydopamine.

M B Youdim.   

Abstract

6-Hydroxydopamine (6-OHDA) inhibits rat brain mitochondrial monoamine oxidase (MAO) when kynuramine or dopamine are used as substrates. The effect is competitive and reversible giving Ki values of 74 and 176 muM with the respective substrates. At high concentrations (5 mM) of each substrate, inhibition of MAO was not observed.

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Year:  1975        PMID： 1164597      PMCID： PMC1666486          DOI： 10.1111/j.1476-5381.1975.tb07583.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  17 in total

1.  Studies of monoamine oxidases: properties of the enzyme in bovine and rabbit brain mitochondria.

Authors:  F M Achee; G Togulga; S Gabay
Journal:  J Neurochem       Date:  1974-05       Impact factor: 5.372

2.  Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo.

Authors:  D S Robinson; W Lovenberg; H Keiser; A Sjoerdsma
Journal:  Biochem Pharmacol       Date:  1968-01       Impact factor: 5.858

3.  Effect of 6-hydroxydopamine on oxidative phosphorylation and on monoamine oxidase activity.

Authors:  K Wagner; U Trendelenburg
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

4.  Monoamine oxidase and aldehyde dehydrogenase activity in the striatum of rats after 6-hydroxydopamine lesion of the nigrostriatal pathway.

Authors:  Y Agid; F Javoy; M B Youdim
Journal:  Br J Pharmacol       Date:  1973-05       Impact factor: 8.739

5.  In vivo generation of hydrogen peroxide from 6-hydroxydopamine.

Authors:  R E Heikkila; G Cohen
Journal:  Experientia       Date:  1972-10-15

6.  Early pre- and postjunctional effects of 6-hydroxydopamine.

Authors:  G Haeusler
Journal:  J Pharmacol Exp Ther       Date:  1971-07       Impact factor: 4.030

7.  Effects of drugs on the 6-hydroxydopamine induced degeneration of adrenergic nerves.

Authors:  G Jonsson; T Malmfors; C Sachs
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1972-05

8.  The kinetics of phenethylhydrazine oxidation by monoamine oxidase.

Authors:  K F Tipton; I P Spires
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857

9.  6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate.

Authors:  R E Heikkila; G Cohen
Journal:  Science       Date:  1973-08-03       Impact factor: 47.728

10.  Inhibition of biogenic amine uptake by hydrogen peroxide: a mechanism for toxic effects of 6-hydroxydopamine.

Authors:  R Heikkila; G Cohen
Journal:  Science       Date:  1971-06-18       Impact factor: 47.728
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