Literature DB >> 467466

In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine.

A Frigerio, P Negrini, L Cappellini, D Rotilio, A De Pascale, E Rossi.   

Abstract

Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule. Its in vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified: dibenzo [c,f] - [1,2]diazepine-1-N-oxide and a monohydroxyderivative in the aromatic ring.

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Year:  1979        PMID： 467466     DOI： 10.1007/BF03189397

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  6 in total

1.  Epoxide-diol pathway in the metabolism of 5H-dibenzo[b,f]-azepine (iminostilbene).

Authors:  C Pantarotto; L Cappellini; A De Pascale; A Frigerio
Journal:  J Chromatogr       Date:  1977-04-11

2.  Identification of desmethylcyproheptadine-10,11-epoxide and other cyproheptadine metabolites isolated from rat urine.

Authors:  A Frigerio; N Sossi; G Belvedere; C Pantarotto; S Garattini
Journal:  J Pharm Sci       Date:  1974-10       Impact factor: 3.534

3.  Gas chromatography of barbiturates, phenolic alkaloids, and xanthine bases: flash-heater methylation by means of trimethylanilinium hydroxide.

Authors:  E Brochmann-Hanssen; T O Oke
Journal:  J Pharm Sci       Date:  1969-03       Impact factor: 3.534

Review 4.  Metabolism and Pharmacolinetics of Carbamazepine.

Authors:  P L Morselli; A Frigerio
Journal:  Drug Metab Rev       Date:  1975       Impact factor: 4.518

Review 5.  Formation of stable epoxides in the metabolism of tricyclic drugs.

Authors:  A Frigerio; M Cavo-Briones; G Belvedere
Journal:  Drug Metab Rev       Date:  1976       Impact factor: 4.518

6.  "Epoxide-diol" metabolic pathway of 5H-dibenzo[a,d]cycloheptene in the rat. Studies by gas chromatography and mass spectrometry.

Authors:  C Pantarotto; L Cappellini; P Negrini; A Frigerio
Journal:  J Chromatogr       Date:  1977-01-21
  6 in total
  1 in total

1.  In vivo studied on the metabolism of dibenzo [c,f]-[1,2] diazepine.

Authors:  A Frigerio; P Negrini; L Cappellini; D Rotilio; A De Pascale; E Rossi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441
  1 in total

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