Literature DB >> 488134

In vivo studied on the metabolism of dibenzo [c,f]-[1,2] diazepine.

A Frigerio, P Negrini, L Cappellini, D Rotilio, A De Pascale, E Rossi.   

Abstract

The in vivo metabolism of dibenzo [c,f]-[1,2] diazepine (I) was studied after i.p. administration to rats, in order to observe the influence of the heteroatom on the metabolic pathway. Metabolites were separated by chromatography and their structures elucidated by mass spectrometry, by both gas chromatography coupled with mass spectrometry and the direct inlet system. Six metabolites were identified, some of them by direct comparison with authentic samples.

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Year:  1979        PMID： 488134     DOI： 10.1007/BF03189403

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  6 in total

1.  Automatic Monitoring of primary amines in preparative column effluents with fluorescamine.

Authors:  P Böhlen; S Stein; J Stone; S Udenfriend
Journal:  Anal Biochem       Date:  1975-08       Impact factor: 3.365

2.  Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range.

Authors:  S Udenfriend; S Stein; P Böhlen; W Dairman; W Leimgruber; M Weigele
Journal:  Science       Date:  1972-11-24       Impact factor: 47.728

3.  Gas chromatography of barbiturates, phenolic alkaloids, and xanthine bases: flash-heater methylation by means of trimethylanilinium hydroxide.

Authors:  E Brochmann-Hanssen; T O Oke
Journal:  J Pharm Sci       Date:  1969-03       Impact factor: 3.534

Review 4.  Formation of stable epoxides in the metabolism of tricyclic drugs.

Authors:  A Frigerio; M Cavo-Briones; G Belvedere
Journal:  Drug Metab Rev       Date:  1976       Impact factor: 4.518

5.  In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine.

Authors:  A Frigerio; P Negrini; L Cappellini; D Rotilio; A De Pascale; E Rossi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441

6.  "Epoxide-diol" metabolic pathway of 5H-dibenzo[a,d]cycloheptene in the rat. Studies by gas chromatography and mass spectrometry.

Authors:  C Pantarotto; L Cappellini; P Negrini; A Frigerio
Journal:  J Chromatogr       Date:  1977-01-21
  6 in total

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