Literature DB >> 870507

Epoxide-diol pathway in the metabolism of 5H-dibenzo[b,f]-azepine (iminostilbene).

C Pantarotto, L Cappellini, A De Pascale, A Frigerio.   

Abstract

5H-Dibenzol[b,f]azepine-10,11-epoxide and 10,11-dihydro-10,11-dihydroxy-5H-dibenzo[b,f]azepine were identified by gas chromatography-mass spectrometry in rat urine as the main biotransformation products in the metabolism of 5H-dibenzo[b,f]azepine (iminostilbene). The presence of these metabolites was confirmed in vitro by incubating iminostilbene with rat liver microsomal enzymes.

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Year:  1977        PMID: 870507     DOI: 10.1016/s0021-9673(00)88527-1

Source DB:  PubMed          Journal:  J Chromatogr


  1 in total

1.  In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine.

Authors:  A Frigerio; P Negrini; L Cappellini; D Rotilio; A De Pascale; E Rossi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1979       Impact factor: 2.441

  1 in total

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