Literature DB >> 4670433

Tilorone hydrochloride: lack of correlation between interferon induction and viral protection.

D J Giron, J P Schmidt, F F Pindak.   

Abstract

The protection of mice against MM virus infection and the induction of circulating interferon by tilorone hydrochloride were determined. Whereas protection was evident with doses of 0.15 and 1.5 mg/kg, interferon was not detected with doses lower than 150 mg/kg. Protection was apparently not dependent on interferon induction.

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Year:  1972        PMID： 4670433      PMCID： PMC444169          DOI： 10.1128/AAC.1.1.78

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Rapid sensitive assay for interferons based on the inhibition of MM virus nucleic acid synthesis.

Authors:  P T Allen; D J Giron
Journal:  Appl Microbiol       Date:  1970-09

2.  Influence of animal genotype and age on the amount of circulating interferoh induced by Newcastle disease virus.

Authors:  E De Maeyer; J De Maeyer-Guignard
Journal:  J Gen Virol       Date:  1968-05       Impact factor: 3.891

3.  Bis-DEAE-fluorenone: mechanism of antiviral protection and stimulation of interferon production in the mouse.

Authors:  E De Clercq; T C Merigan
Journal:  J Infect Dis       Date:  1971-02       Impact factor: 5.226

4.  Gene with quantitative effect on circulating interferon induced by Newcastle disease virus.

Authors:  E de Maeyer; J de Maeyer-Guignard
Journal:  J Virol       Date:  1969-05       Impact factor: 5.103

5.  Tilorone hydrochloride: an orally active antiviral agent.

Authors:  R E Krueger; G D Mayer
Journal:  Science       Date:  1970-09-18       Impact factor: 47.728

6.  Tilorone hydrochloride: mode of action.

Authors:  G D Mayer; R F Krueger
Journal:  Science       Date:  1970-09-18       Impact factor: 47.728
  6 in total
  7 in total

1.  Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.

Authors:  Sean Ekins; Mary A Lingerfelt; Jason E Comer; Alexander N Freiberg; Jon C Mirsalis; Kathleen O'Loughlin; Anush Harutyunyan; Claire McFarlane; Carol E Green; Peter B Madrid
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

2.  Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride.

Authors:  E Katz; E Margalith; B Winer
Journal:  Antimicrob Agents Chemother       Date:  1976-01       Impact factor: 5.191

3.  Comparison of the ability of small molecular interferon inducers: tilorone and acridine drugs.

Authors:  E T Gláz; M Tálas
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

4.  Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats.

Authors:  Viktoriya Keyer; Laura Syzdykova; Gulzat Zauatbayeva; Aigerim Zhulikeyeva; Yerlan Ramanculov; Alexandr V Shustov; Zarina Shulgau
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-17

5.  Evaluation of various analogues of tilorone hydrochloride against Venezuelan equine encephalitis virus in mice.

Authors:  R W Kuehne; W L Pannier; E L Stephen
Journal:  Antimicrob Agents Chemother       Date:  1977-01       Impact factor: 5.191

6.  Induction of cytokines by tilorone hydrochloride.

Authors:  W Zschiesche; B Fahlbusch; I Schumann; E Tonew
Journal:  Agents Actions       Date:  1978-10

7.  Effects of tilorone on hemopoietic stem cells and on the development of Friend leukemia.

Authors:  H J Seidel; U Opitz; L Kreja
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333
  7 in total

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